Maruyama Y, Satoh S, Watanabe J, Ashikawa K, Isoyama S, Suzuki H, Ino-Oka E, Takishima T
Jpn Heart J. 1986 May;27(3):329-43. doi: 10.1536/ihj.27.329.
We investigated whether the relationship between the mean left anterior descending and septal coronary blood flow and the mean perfusion pressure varies with left circumflex coronary stenosis. We used excised, perfused canine heart preparations (n = 10), in which variables to influence the myocardial oxygen demand and supply relation can be fairly well controlled. The results showed that coronary blood flow in the adjacent, non-stenosed coronary artery increased significantly following LCX stenosis; this increased flow was found at the same values of heart rate, left ventricular end-diastolic pressure and perfusion pressure, as those in the preischemic state. Moreover, this increased flow was also observed when the values of peak left ventricular pressure and pressure-length loop area were similar between the pre-ischemic and ischemic states. Thus, contributions of neurohumoral factors or alterations in mechanical factors determining the myocardial oxygen demand and supply relation are negligible. This increased flow may be important in maintaining overall cardiac function in cases of acute coronary stenosis or coronary occlusion.
我们研究了左前降支与间隔冠状动脉平均血流和平均灌注压之间的关系是否随左旋支冠状动脉狭窄而变化。我们使用了切除并灌注的犬心标本（n = 10），在该标本中，影响心肌氧需求和供应关系的变量可以得到较好的控制。结果表明，左旋支冠状动脉狭窄后，相邻的非狭窄冠状动脉的血流显著增加；在与缺血前状态相同的心率、左心室舒张末期压力和灌注压值时，发现血流增加。此外，当缺血前和缺血状态下左心室峰值压力和压力-长度环面积值相似时，也观察到了这种血流增加。因此，神经体液因素或决定心肌氧需求和供应关系的机械因素改变的作用可以忽略不计。这种血流增加在急性冠状动脉狭窄或冠状动脉闭塞的情况下，对于维持整体心脏功能可能很重要。
