Department of Cell Biology, Calhoun Cardiology Center, University of Connecticut School of Medicine, Farmington, CT, USA.
Adv Neurobiol. 2023;33:171-202. doi: 10.1007/978-3-031-34229-5_7.
Voltage-gated calcium channels (VGCCs), especially Ca2.1 and Ca2.2, are the major mediators of Ca influx at the presynaptic membrane in response to neuron excitation, thereby exerting a predominant control on synaptic transmission. To guarantee the timely and precise release of neurotransmitters at synapses, the activity of presynaptic VGCCs is tightly regulated by a variety of factors, including auxiliary subunits, membrane potential, G protein-coupled receptors (GPCRs), calmodulin (CaM), Ca-binding proteins (CaBP), protein kinases, various interacting proteins, alternative splicing events, and genetic variations.
电压门控钙通道（VGCCs），尤其是 Ca2.1 和 Ca2.2，是神经元兴奋时突触前膜钙内流的主要介导物，从而对突触传递发挥主要控制作用。为了保证神经递质在突触处的及时和精确释放，突触前 VGCC 的活性受到多种因素的严格调节，包括辅助亚基、膜电位、G 蛋白偶联受体（GPCRs）、钙调蛋白（CaM）、钙结合蛋白（CaBP）、蛋白激酶、各种相互作用蛋白、可变剪接事件和遗传变异。
