Dremin S A, Aniukhovskiĭ E P, Rozenshtraukh L V, Hageman G R, Urtaler F
Kardiologiia. 1986 Aug;26(8):10-5.
The effect of a new anti-arrhythmic drug etacysin was studied in various forms of dog Purkinje's fibres automativity: normal and abnormal arising at a late stage of experimental myocardial infarction (24 hrs after coronary artery ligation) and induced by ions Ba2+. An average 57% decrease in the frequency of automaticity of normal Purkinje's fibres due to steepening the slope of slow diastolic depolarization and almost complete depression of an abnormal one was observed for the drug concentrations 5 X 10(-7) and 10(-6) g/ml. Reduced automaticity was also related to decreased slow diastolic depolarization. Maximal values of diastolic potential were found unchanged.
正常自律性以及实验性心肌梗死晚期（冠状动脉结扎后24小时）出现的异常自律性，还有由Ba2+离子诱导产生的自律性。对于浓度为5×10(-7)和10(-6) g/ml的该药物，观察到正常浦肯野纤维的自律性频率平均降低了57%，这是由于缓慢舒张期去极化斜率变陡，且异常自律性几乎完全受到抑制。自律性降低还与缓慢舒张期去极化的减少有关。舒张电位的最大值未发生变化。
