人类胚胎模型：国家政策和治理审查的重要性。

Human embryo models: the importance of national policy and governance review.

机构信息

Wellcome Trust, CRUK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.

The Faculty of Law, The David Williams Building, 10 West Road, Cambridge CB3 9DZ, UK; Cambridge Reproduction, University of Cambridge, Physiology Building, Cambridge CB2 3EG, UK.

出版信息

Curr Opin Genet Dev. 2023 Oct;82:102103. doi: 10.1016/j.gde.2023.102103. Epub 2023 Aug 22.

DOI:10.1016/j.gde.2023.102103

PMID:37619506

Abstract

Integrated and non-integrated stem cell-based embryo models are becoming widely adopted tools in biomedical research with distinct advantages over animal models for studying human development. Although SCB-EMs have tremendous benefits for research, they raise a number of social, ethical and legal questions that affect future research and widespread adoption in industry and clinical settings. The 2021 International Society for Stem Cell Research Guidelines for Stem Cell Research and Clinical Translation provide helpful guidance on many of these issues but do not have force in domestic law. Careful appraisal and development of national legal and ethical frameworks is crucial. Paving the way to better regulation provides an ethical and social foundation to continue using human embryo models and to fully realise their potential benefits for reproductive medicine.

摘要

基于干细胞的整合与非整合胚胎模型正日益成为生物医学研究中的广泛应用工具，其在研究人类发育方面相较于动物模型具有明显优势。尽管 SCB-EM 对研究具有巨大的益处，但它们也引发了许多社会、伦理和法律问题，这些问题影响着未来的研究以及在工业和临床环境中的广泛应用。2021 年国际干细胞研究学会关于干细胞研究和临床转化的指南为这些问题中的许多问题提供了有益的指导，但在国内法律中并不具有约束力。仔细评估和制定国家法律和伦理框架至关重要。为更好的监管铺平道路，为继续使用人类胚胎模型并充分实现其在生殖医学方面的潜在益处提供了伦理和社会基础。