Reis José Augusto Silva, Rossi Giordano Novak, L Osório Flávia, Bouso José Carlos, Hallak Jaime Eduardo Cecílio, Dos Santos Rafael Guimarães
Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University São Paulo, SP, Brazil.
Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University São Paulo, SP, Brazil; National Institute for Translational Medicine (INCT-TM), CNPq, Brazil.
Neurosci Biobehav Rev. 2023 Oct;153:105367. doi: 10.1016/j.neubiorev.2023.105367. Epub 2023 Aug 22.
The recognition of emotions in facial expressions (REFE) is a core construct of social cognition. In the last decades, studies have showed that REFE is altered in major depressive disorder (MDD), but the evidence is conflicting. Thus, we conducted a systematic review of clinical trials involving therapeutic interventions in MDD and any evaluation of REFE to update (2018-2023) and systematically evaluate the evidence derived from controlled clinical trials on the effects of therapeutic strategies to MDD on the REFE. Eleven studies were included in the final review. Some interventions, including drugs (ketamine, bupropion, psylocibin) and non-pharmacological strategies (psychotherapy) seem to be able to reduce pre-existing REFE biases in MDD patients. However, there was a high heterogeneity in the evaluated studies, in terms of sample, interventions, tasks and results. Further studies and more consistent evaluation tools are highly needed to better understand nuanced deficits and specific actions of different treatment options.
面部表情情绪识别（REFE）是社会认知的核心构成。在过去几十年中，研究表明，重度抑郁症（MDD）患者的REFE会发生改变，但证据相互矛盾。因此，我们对涉及MDD治疗干预以及REFE任何评估的临床试验进行了系统综述，以更新（2018 - 2023年）并系统评估来自对照临床试验的证据，这些证据涉及治疗策略对MDD患者REFE的影响。最终综述纳入了11项研究。一些干预措施，包括药物（氯胺酮、安非他酮、裸盖菇素）和非药物策略（心理治疗）似乎能够减少MDD患者先前存在的REFE偏差。然而，在评估研究中，在样本、干预措施、任务和结果方面存在高度异质性。迫切需要进一步的研究和更一致的评估工具，以更好地理解不同治疗方案的细微缺陷和具体作用。
