Wang ZheHui, Chen YuJie, Yang Xin, Pan BaiLin, Xie HongBin, Bi HongSen
Department of Plastic Surgery, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.
Aesthetic Plast Surg. 2024 Jan;48(2):228-235. doi: 10.1007/s00266-023-03590-x. Epub 2023 Aug 24.
We aimed to investigate the safety and efficacy of laser or intense pulsed light therapy for early treatment of surgical scar.
A literature search was conducted for relevant prospective, randomized controlled trials published in PubMed, Embase, Web of Science, Cochrane Library, CNKI, WanFang Database, and VTTMS between January 2006 and January 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist was used to extract literature data. The risk of bias was assessed by RevMan. Safety was assessed based on the presence of serious adverse reactions (blisters, infections, burns above the second degree), while effectiveness was assessed using the Vancouver Score Scale.
1512 related articles were preliminarily retrieved, including 1211 English articles and 301 Chinese articles. According to the inclusion criteria and exclusion criteria, 12 articles were selected for this analysis. In total, 475 patients were included (laser group, 238; control group, 236). All studies confirmed that the laser group was superior to the control group. In the subgroup analysis of 7 articles, the standardized mean difference was 1.99 (P = 0.0001).
This meta-analysis demonstrates that laser or intense pulsed light therapy is a safe and effective approach for early surgical scar treatment, resulting in improved scar appearance and minimal adverse reactions.
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
我们旨在研究激光或强脉冲光疗法早期治疗手术瘢痕的安全性和有效性。
检索2006年1月至2022年1月期间发表在PubMed、Embase、Web of Science、Cochrane图书馆、中国知网、万方数据库和维普资讯等数据库中的相关前瞻性随机对照试验。使用系统评价和Meta分析的首选报告项目清单提取文献数据。采用RevMan评估偏倚风险。根据严重不良反应（水泡、感染、二度以上烧伤）的发生情况评估安全性，使用温哥华评分量表评估有效性。
初步检索到1512篇相关文章，其中英文文章1211篇，中文文章301篇。根据纳入标准和排除标准，选取12篇文章进行本分析。共纳入475例患者（激光组238例，对照组236例）。所有研究均证实激光组优于对照组。在7篇文章的亚组分析中，标准化均数差为1.99（P = 0.0001）。
本Meta分析表明，激光或强脉冲光疗法是早期手术瘢痕治疗的一种安全有效的方法，可改善瘢痕外观，不良反应最小。
证据级别I：本刊要求作者为每篇文章指定证据级别。有关这些循证医学评级的完整描述，请参阅目录或作者在线指南www.springer.com/00266 。
