Hards R G, Patterson D
Mech Ageing Dev. 1986 Sep;36(1):65-70. doi: 10.1016/0047-6374(86)90139-9.
The levels of glycinamide ribonucleotide synthetase were monitored in four human fibroblast cell lines, two diploid, one monosomy 21 and one trisomy 21, from early passage number to senescence. In all four lines, enzyme activity increased as the cells aged. Enzyme levels for the diploid versus trisomy 21 cells did not consistently exhibit the expected gene dosage effect.
在四种人类成纤维细胞系中监测了甘氨酰胺核糖核苷酸合成酶的水平，这四种细胞系分别为两种二倍体细胞系、一种21号染色体单体细胞系和一种21号染色体三体细胞系，从传代早期到衰老阶段进行监测。在所有四种细胞系中，随着细胞老化，酶活性增加。二倍体细胞与21号染色体三体细胞的酶水平并未始终呈现出预期的基因剂量效应。
