Xuan Xiaoyu, Zhang Shiliang
First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Cardiology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Phytother Res. 2023 Dec;37(12):5495-5508. doi: 10.1002/ptr.7992. Epub 2023 Aug 25.
Diabetic cardiomyopathy (DCM) is one of the severe complications of diabetes, characterized by structural and functional abnormalities in the hearts of diabetic patients without hypertension, coronary heart disease, or valvular heart disease. DCM can progress to heart failure, which is a significant cause of death in diabetic patients, but currently, there is no effective treatment available. Programmed cell death (PCD) is a genetically regulated form of cell death that includes apoptosis, autophagy, necroptosis, ferroptosis, and pyroptosis. PCD is essential for tissue homeostasis and normal development of the body. DCM is a complex condition, and abnormalities in the cascade of PCD signaling have been observed in its pathological process, suggesting that targeting PCD could be a potential therapeutic strategy. Studies have shown that natural substances can effectively modulate PCD to intervene in the treatment of DCM, and their use is safe. This review explores the role of different forms of PCD in the pathogenesis of DCM and summarizes the research progress in targeting PCD with natural substances to treat DCM. It can serve as a basis for further research and drug development to provide new treatment strategies for DCM patients.
糖尿病性心肌病（DCM）是糖尿病的严重并发症之一，其特征是糖尿病患者的心脏出现结构和功能异常，且无高血压、冠心病或心脏瓣膜病。DCM可进展为心力衰竭，这是糖尿病患者死亡的重要原因，但目前尚无有效的治疗方法。程序性细胞死亡（PCD）是一种由基因调控的细胞死亡形式，包括凋亡、自噬、坏死性凋亡、铁死亡和焦亡。PCD对组织稳态和身体的正常发育至关重要。DCM是一种复杂的病症，在其病理过程中已观察到PCD信号级联的异常，这表明靶向PCD可能是一种潜在的治疗策略。研究表明，天然物质可以有效地调节PCD以干预DCM的治疗，并且其使用是安全的。本综述探讨了不同形式的PCD在DCM发病机制中的作用，并总结了用天然物质靶向PCD治疗DCM的研究进展。它可为进一步的研究和药物开发提供依据，为DCM患者提供新的治疗策略。
