Werkhaven J, Harris D M, Krol G, Hill J H
Laryngoscope. 1986 Oct;96(10):1058-61. doi: 10.1288/00005537-198610000-00002.
Photodynamic therapy (PDT) for treatment of head and neck cancer uses a photoactive compound that is illuminated with 630 nm (red) light. The effectiveness of PDT depends on the penetration of light into tissue that is both tissue and wavelength dependent. The characterization of the optical properties of an animal oral mucosa and skin has been done to determine the amount of light below these tissues available to be used for photodynamic therapy. The tissue absorbance of visible light from 400 nm to 700 nm has been determined in vitro for hamster check pouch mucosa and for athymic mouse skin. The pattern of absorbance is similar for both tissues and demonstrates greater transmission at the longer wavelengths. The diffuse transmittance of light in vivo for these animal models was measured with an interstitial fiberoptic probe. At 630 nm the diffuse transmittance for nude mouse skin averages 10% of the incident light energy, and that for the hamster mucosa almost 50% of the incident light energy.
用于治疗头颈癌的光动力疗法（PDT）使用一种光活性化合物，该化合物用630纳米（红色）光照射。光动力疗法的有效性取决于光穿透组织的情况，而这既取决于组织，也取决于波长。已经对动物口腔黏膜和皮肤的光学特性进行了表征，以确定可用于光动力疗法的这些组织下方的光量。已在体外测定了仓鼠颊囊黏膜和无胸腺小鼠皮肤在400纳米至700纳米可见光范围内的组织吸光度。两种组织的吸光度模式相似，且在较长波长处表现出更高的透射率。使用间质光纤探头测量了这些动物模型体内光的漫透射率。在630纳米处，裸鼠皮肤的漫透射率平均为入射光能的10%，而仓鼠黏膜的漫透射率几乎为入射光能的50%。
