血脂异常背景下年轻人脂肪细胞因子与早期肾功能障碍的关联

Associations of Adipocytokines and Early Renal Dysfunction in Young People on the Background of Dyslipidemia.

作者信息

Garbuzova Evgeniia V, Khudiakova Alyona D, Shcherbakova Lilia V, Kashtanova Elena V, Polonskaya Yana V, Stakhneva Ekaterina M, Ragino Yulia I

机构信息

Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), B. Bogatkova Str., 175/1, 630089 Novosibirsk, Russia.

出版信息

J Pers Med. 2023 Aug 9;13(8):1238. doi: 10.3390/jpm13081238.

DOI:10.3390/jpm13081238

PMID:37623488

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10455902/

Abstract

BACKGROUND

There are data supporting the idea that atherogenic dyslipidemia is a risk factor for CKD and reduced GFR. The aim was to evaluate the associations between adipocytokines and early renal dysfunction in young people with dyslipidemia.

MATERIALS AND METHODS

A population study was conducted in IIPM-Branch of IC&G SB RAS, in 2013-2017. Furthermore, 1033 people were included in the study (469 men (45.4%) and 564 women (54.6%)). The study included blood sampling, anthropometric data, and adipokines by multiplex analysis.

RESULTS

Among people with reduced kidney function and DLP, men were 3.1 times more common than without DLP, women smoked 2 times less often, arterial hypertension was 7.8 times more common, and abdominal obesity was 2.7 times more common (and women with DLP were 3 times more likely than those without DLP). An increase in the level of resistin by 1 mcg/mL was associated with an increased chance of having renal dysfunction by 0.2%. An increase in the level of GIP was associated with an increased chance of having renal dysfunction by 1.1%.

CONCLUSIONS

In young people with dyslipidemia, regardless of the presence of abdominal obesity, resistin and GIP are associated with the presence of renal dysfunction.

摘要

背景

有数据支持动脉粥样硬化性血脂异常是慢性肾脏病（CKD）和肾小球滤过率（GFR）降低的危险因素这一观点。目的是评估血脂异常的年轻人中脂肪细胞因子与早期肾功能不全之间的关联。

材料与方法

2013 - 2017年在俄罗斯科学院西伯利亚分院生物医学问题研究所IIPM分所进行了一项人群研究。此外，1033人纳入研究（469名男性（45.4%）和564名女性（54.6%））。该研究包括血液采样、人体测量数据以及通过多重分析检测脂肪细胞因子。

结果

在肾功能降低和血脂异常（DLP）的人群中，男性比无血脂异常者常见3.1倍，女性吸烟频率低2倍，动脉高血压常见7.8倍，腹型肥胖常见2.7倍（且有血脂异常的女性比无血脂异常者可能性高3倍）。抵抗素水平每增加1 mcg/mL，肾功能不全的发生几率增加0.2%。胃抑制多肽（GIP）水平升高与肾功能不全发生几率增加1.1%相关。