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将肽RWQWRWQWR与[提取物名称]的乙醇提取物相结合可增强对敏感和耐药[菌株名称]及[菌株名称]的活性。 你提供的原文中“Enhances the Activity against Sensitive and Resistant and Strains.”部分信息不完整，我按照完整的翻译思路进行了补充翻译，你可以根据实际情况修改。

Combining the Peptide RWQWRWQWR and an Ethanolic Extract of Enhances the Activity against Sensitive and Resistant and Strains.

作者信息

Vargas-Casanova Yerly, Bravo-Chaucanés Claudia Patricia, Martínez Andrea Ximena Hernández, Costa Geison Modesti, Contreras-Herrera Jorge Luis, Medina Ricardo Fierro, Rivera-Monroy Zuly Jenny, García-Castañeda Javier Eduardo, Parra-Giraldo Claudia Marcela

机构信息

Microbiology Department, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.

Chemistry Department, Faculty of Sciences, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.

出版信息

J Fungi (Basel). 2023 Aug 2;9(8):817. doi: 10.3390/jof9080817.

DOI:10.3390/jof9080817
PMID:37623588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10455339/
Abstract

The antifungal activity of palindromic peptide RWQWRWQWR and its derivatives was evaluated against clinical isolates of and . Also, ethanolic extracts of leaves and stem were evaluated. Furthermore, combinations of peptide, extract, and/or fluconazole (FLC) were evaluated. The cytotoxicity of peptides and extracts in erythrocytes and fibroblasts was determined. The original palindromic peptide, some derivative peptides, and the ethanolic extract of leaves of exhibited the highest activity in some of the strains evaluated. Synergy was obtained between the peptide and the FLC against 435. The combination of the extract and the original palindromic peptide against SC5314, 435, and 537 decreased the minimal inhibitory concentrations (MICs) by a factor of between 4 and 16. These mixtures induced changes in cell morphology, such as deformations on the cell surface. The results suggest that the combination of RWQWRWQWR and extract is an alternative for enhancing antifungal activity and decreasing cytotoxicity and costs and should be considered to be a promising strategy for treating diseases caused by spp.

摘要

评估了回文肽RWQWRWQWR及其衍生物对[具体菌种1]和[具体菌种2]临床分离株的抗真菌活性。此外，还评估了[植物名称]叶片和茎的乙醇提取物。此外，还评估了肽、提取物和/或氟康唑（FLC）的组合。测定了肽和提取物对红细胞和成纤维细胞的细胞毒性。原始回文肽、一些衍生肽以及[植物名称]叶片的乙醇提取物在某些评估菌株中表现出最高活性。肽与FLC联合对[菌种3] 435表现出协同作用。提取物与原始回文肽联合对[菌种4] SC5314、[菌种3] 435和[菌种5] 537的最小抑菌浓度（MIC）降低了4至16倍。这些混合物引起细胞形态变化，如细胞表面变形。结果表明，RWQWRWQWR与[植物名称]提取物联合使用是增强抗真菌活性、降低细胞毒性和成本的一种选择，应被视为治疗由[菌种属名] spp.引起疾病的一种有前景的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/241f9ffc3226/jof-09-00817-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/52f17dabbce8/jof-09-00817-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/9c29a39d59d8/jof-09-00817-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/87bd40889a4a/jof-09-00817-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/6519678cacf4/jof-09-00817-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/44cec50d7365/jof-09-00817-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/6bbc2df17bae/jof-09-00817-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/ee7f7dc10f2e/jof-09-00817-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/2720c0da1988/jof-09-00817-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/6bbc7f2eb343/jof-09-00817-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/241f9ffc3226/jof-09-00817-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/52f17dabbce8/jof-09-00817-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/9c29a39d59d8/jof-09-00817-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/87bd40889a4a/jof-09-00817-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/6519678cacf4/jof-09-00817-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/44cec50d7365/jof-09-00817-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/6bbc2df17bae/jof-09-00817-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/ee7f7dc10f2e/jof-09-00817-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/2720c0da1988/jof-09-00817-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/6bbc7f2eb343/jof-09-00817-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ec/10455339/241f9ffc3226/jof-09-00817-g010.jpg

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