Murthy Jagarlapudi M K
Department of Neurology, CARE Hospitals, Banjara Hills, Hyderabad 500034, Telengana, India.
Pathogens. 2023 Aug 14;12(8):1037. doi: 10.3390/pathogens12081037.
The calcified stage of the neurocysticercosis (NCC) is the common cause of acquired epilepsy in low and middle income countries in people aged > 20 years. Approximately 30% of adult onset seizures and epilepsy are attributable to NCC. In India and some of the Latin American countries, epilepsy due to solitary calcified NCC is the common adult onset epilepsy. The current evidence suggests that the calcified cysticercus granuloma is probably the epileptogenic focus. The mechanisms involved in the epileptogenic process are not well understood; Focal-onset seizures with or without impaired awareness are the common seizure type. Focal-onset seizure can evolve to bilateral tonic-clonic seizure. Seizure outcome with anti-seizure medication, most often with monotherapy, is very good. The seizure disorders associated with various stages of NCC can be preventable.
神经囊尾蚴病(NCC)的钙化期是中低收入国家20岁以上人群后天性癫痫的常见病因。约30%的成人发作性癫痫和癫痫归因于NCC。在印度和一些拉丁美洲国家,由孤立性钙化NCC引起的癫痫是常见的成人发作性癫痫。目前的证据表明,钙化的囊尾蚴肉芽肿可能是致痫灶。致痫过程中涉及的机制尚不清楚;伴有或不伴有意识障碍的局灶性发作是常见的发作类型。局灶性发作可演变为双侧强直阵挛发作。使用抗癫痫药物治疗癫痫,多数情况下采用单药治疗,效果非常好。与NCC不同阶段相关的癫痫障碍是可以预防的。