鉴定 STRN3-RARA 为急性早幼粒细胞白血病的新融合基因。
Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia.
机构信息
Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
Blood. 2023 Oct 26;142(17):1494-1499. doi: 10.1182/blood.2023020619.
Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.
在这里，我们报道了一种新的融合基因 STRN3-RARA，存在于急性早幼粒细胞白血病（APL）中。它与 UTX 缺失共同作用，在小鼠中驱动全反式维甲酸治疗后复发的 APL。虽然 STRN3-RARA 白血病在全反式维甲酸治疗后很快复发，但它可以被塞卡菌素所抑制。
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