子宫内膜相关疾病中的人参皂苷：作用机制及新发现

Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms.

机构信息

Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People's Republic of China; Shanghai Medical College, Fudan University, Shanghai 200032, People's Republic of China.

Institute of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200080, People's Republic of China.

出版信息

Biomed Pharmacother. 2023 Oct;166:115340. doi: 10.1016/j.biopha.2023.115340. Epub 2023 Aug 23.

DOI:10.1016/j.biopha.2023.115340

PMID:37625321

Abstract

Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesenchymal transition (EMT) in endometrium-related cells, and activating the immune system to kill cells associated with endometrial diseases. We hope to provide a theoretical foundation for the treatment of endometrium-related diseases by ginsenosides.

摘要

人参皂苷是从一种重要草药（人参）中提取的物质，有望为子宫内膜相关疾病提供新的治疗方法。基于人参皂苷的分子类型，我们综述了人参皂苷对子宫内膜相关疾病（如子宫内膜癌、子宫内膜异位症和子宫内膜炎）的主要药理作用。人参皂苷的作用机制涉及诱导子宫内膜相关细胞凋亡、促进子宫内膜相关细胞自噬、调节子宫内膜相关细胞上皮间质转化（EMT）以及激活免疫系统杀死与子宫内膜疾病相关的细胞。我们希望为人参皂苷治疗子宫内膜相关疾病提供理论基础。