Department of Pathology, Aga Khan University Hospital, Nairobi, Kenya
Department of Pathology, Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
Ann Clin Lab Sci. 2023 Jul;53(4):641-646.
A review of the clinical-pathologic characteristics and outcomes of biphasic polyps occurring in the female genital tract, not meeting the diagnostic criteria of Mullerian Adenosarcoma (MA).
An archival database search was run, after IRB approval, between 2001 and 2019, using terminology such as "Mullerian adenofibroma," "atypical Mullerian adenofibroma," "polypoid adenofibroma," and "atypical polyp with increased stromal cellularity." Two pathologists (JW and MRQ) reviewed all the retrieved cases and documented the morphologic features with particular emphasis on the presence of any features of Mullerian adenosarcoma. Follow-up data were also abstracted.
Twenty-one cases, 12 cervical and 9 endometrial lesions, constituted the study cohort. Patients ranged from 26 to 64 years (median 49 years). On review, 20 of 21 of those cases showed Phyllodes-like architectural patterns. However, only one case showed all four features of MA, all of which were focal and inconspicuous. Follow-up (median duration of 5 years) did not document any recurrences in any of the 21 cases after excision.
This series adds to the growing body of literature affirming the existence of benign biphasic Mullerian polyps encountered in the endometrium and cervix that fall short of the Mullerian adenosarcoma diagnosis.
回顾女性生殖道中发生的不符合苗勒管腺肉瘤（Mullerian Adenosarcoma，MA）诊断标准的双相性息肉的临床病理特征和结局。
经机构审查委员会（IRB）批准，我们在 2001 年至 2019 年期间，使用“Mullerian adenofibroma”、“atypical Mullerian adenofibroma”、“polypoid adenofibroma”和“atypical polyp with increased stromal cellularity”等术语，进行了存档数据库检索。两位病理学家（JW 和 MRQ）审查了所有检索到的病例，并记录了形态特征，特别强调了是否存在任何 MA 的特征。还提取了随访数据。
21 例病例，其中 12 例为宫颈病变，9 例为子宫内膜病变，构成了研究队列。患者年龄从 26 岁至 64 岁（中位数为 49 岁）。经审查，21 例中有 20 例显示出 Phyllodes 样结构模式。然而，只有 1 例显示出 MA 的所有 4 个特征，且均为局灶性和不明显的。切除后随访（中位随访时间为 5 年）未发现任何 21 例病例的复发。
本系列研究增加了越来越多的文献，证实了在子宫内膜和宫颈中存在良性双相性苗勒管息肉，这些息肉不符合 MA 的诊断标准。
