Chen Xiaofei, Cook Riley, Filbey Francesca M, Nguyen Hang, McColl Roderick, Jeon-Slaughter Haekyung
Department of Statistics and Data Science, Southern Methodist University, Dallas, TX 75205, USA.
VA North Texas Health Care Service, Dallas, TX 75216, USA.
Brain Sci. 2023 Aug 4;13(8):1164. doi: 10.3390/brainsci13081164.
Cigarette smoking is believed to accelerate age-related neurodegeneration. Despite significant sex differences in both smoking behaviors and brain structures, the active literature is equivocal in parsing out a sex difference in smoking-associated brain structural changes.
The current study examined subcortical and lateral ventricle gray matter (GM) volume differences among smokers, active, past, and never-smokers, stratified by sex.
The current study data included 1959 Dallas Heart Study (DHS) participants with valid brain imaging data. Stratified by gender, multiple-group comparisons of three cigarette-smoking groups were conducted to test whether there is any cigarette-smoking group differences in GM volumes of the selected regions of interest (ROIs).
The largest subcortical GM volumetric loss and enlargement of the lateral ventricle were observed among past smokers for both females and males. However, these observed group differences in GM volumetric changes were statistically significant only among males after adjusting for age and intracranial volumes.
The study findings suggest a sex difference in lifetime-smoking-associated GM volumetric changes, even after controlling for aging and intracranial volumes.
人们认为吸烟会加速与年龄相关的神经退行性变。尽管吸烟行为和脑结构存在显著的性别差异，但现有文献在解析吸烟相关脑结构变化中的性别差异方面并不明确。
本研究按性别分层，考察吸烟者、当前吸烟者、既往吸烟者和从不吸烟者之间的皮质下和侧脑室灰质（GM）体积差异。
本研究数据包括1959名达拉斯心脏研究（DHS）参与者的有效脑成像数据。按性别分层，对三个吸烟组进行多组比较，以检验所选感兴趣区域（ROI）的GM体积在吸烟组之间是否存在差异。
既往吸烟者中，无论男性还是女性，皮质下GM体积损失最大，侧脑室扩大。然而，在调整年龄和颅内体积后，这些观察到的GM体积变化的组间差异仅在男性中具有统计学意义。
研究结果表明，即使在控制了衰老和颅内体积后，终生吸烟相关的GM体积变化仍存在性别差异。
