Montes-Herrera Daniel, Muñoz-Medina José Esteban, Fernandes-Matano Larissa, Salas-Lais Angel Gustavo, Hernández-Cueto Ma De Los Ángeles, Santacruz-Tinoco Clara Esperanza, Monroy-Muñoz Irma Eloisa, Angeles-Martínez Javier
Central Epidemiology Laboratory, Mexican Social Security Institute, Mexico City 02990, Mexico.
Quality of Supplies and Specialized Laboratories Coordination, Mexican Social Security Institute, Mexico City 07760, Mexico.
Diagnostics (Basel). 2023 Aug 9;13(16):2630. doi: 10.3390/diagnostics13162630.
Obesity is associated with an increased risk of contracting infections. This study aimed to estimate the risk of COVID-19 infection associated with obesity and to assess its role in the specific antibody response against SARS-CoV-2 in 2021. This study included 980 participants from the State of Mexico who participated in a serological survey where they were tested for SARS-CoV-2 IgG anti-S1/S2 and anti-RBD antibodies and asked for height, weight, and previous infection data via a questionnaire. Of the cohort of 980 participants, 451 (46.02%) were seropositive at the time of recruitment (45.2% symptomatic and 54.8% asymptomatic). The risk of SARS-CoV-2 infection with obesity was 2.18 (95% CI: 1.51-3.16), 2.58 (95% CI: 1.63-4.09), and 1.88 (95% CI: 1.18-2.98) for seropositive, asymptomatic, and symptomatic individuals, respectively, compared to those with normal weight. Anti-S1/S2 and anti-RBD IgG antibodies tended to be higher in overweight and obese participants in the seropositive group and stratified by different obesity classes. Additionally, there was a positive correlation between anti-S1/S2 and anti-RBD IgG antibodies and BMI in both men and women in the seropositive group. Obesity is an independent risk factor for SARS-CoV-2 infection when adjusted for confounding variables; however, the relationship between BMI and anti-S1/S2 and anti-RBD IgG antibody levels differed markedly in the presence or absence of symptoms.
肥胖与感染风险增加有关。本研究旨在评估2021年肥胖与新冠病毒感染风险之间的关联，并评估肥胖在针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的特异性抗体反应中的作用。本研究纳入了来自墨西哥州的980名参与者，他们参与了一项血清学调查，接受了SARS-CoV-2 IgG抗S1/S2和抗受体结合域（RBD）抗体检测，并通过问卷调查提供身高、体重和既往感染数据。在这980名参与者队列中，451人（46.02%）在招募时血清学呈阳性（45.2%有症状，54.8%无症状）。与体重正常者相比，血清学呈阳性、无症状和有症状的肥胖个体感染SARS-CoV-2的风险分别为2.18（95%置信区间：1.51 - 3.16）、2.58（95%置信区间：1.63 - 4.09）和1.88（95%置信区间：1.18 - 2.98）。在血清学呈阳性组中，按不同肥胖类别分层后，超重和肥胖参与者的抗S1/S2和抗RBD IgG抗体往往更高。此外，血清学呈阳性组的男性和女性中，抗S1/S2和抗RBD IgG抗体与体重指数（BMI）之间均呈正相关。在对混杂变量进行校正后，肥胖是SARS-CoV-2感染的独立危险因素；然而，BMI与抗S1/S2和抗RBD IgG抗体水平之间的关系在有无症状的情况下有显著差异。
