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脂肪组织去神经支配削弱了肥胖引起的大鼠骨形成减少。

Adipose Tissue Denervation Blunted the Decrease in Bone Formation Promoted by Obesity in Rats.

机构信息

Nephrology Division, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.

Department of Physiology, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.

出版信息

Nutrients. 2023 Aug 14;15(16):3574. doi: 10.3390/nu15163574.

DOI:10.3390/nu15163574
PMID:37630764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10458609/
Abstract

The impact of obesity upon bone metabolism is controversial since both beneficial or harmful effects have been reported. Bone remodeling is modulated by the central nervous system through cytokines, hormones and neuromodulators. The present study aimed to evaluate the effects evoked by bilateral retroperitoneal white adipose tissue (rWAT) denervation (Dnx) upon bone mineral metabolism and remodeling in an experimental model of obesity in rats. Male Wistar rats were fed during 18 weeks with high-fat diet (HFD) or standard diet (SD) as controls, and rWAT Dnx or Sham surgery was performed at the 14th week. Biochemical and hormonal parameters, bone histomorphometry, rWAT and hypothalamus protein and gene expression were analyzed. The HFD group presented decreased bone formation parameters, increased serum and bone leptin and FGF23, increased serum and hypothalamic neuropeptide Y (NPY) and decreased serum 1,25-dihydroxyvitamin D and PTH. After rWAT Dnx, bone markers and histomorphometry showed restoration of bone formation, and serum and hypothalamic NPY decreased, without alteration in leptin levels. The present study shows that the denervation of rWAT improved bone formation in obese rats mediated by a preferential reduction in neurohormonal actions of NPY, emphasizing the relevance of the adipose tissue-brain-bone axis in the control of bone metabolism in obesity.

摘要

肥胖对骨代谢的影响存在争议，因为已有研究报道其具有有益和有害双重作用。骨重塑受中枢神经系统通过细胞因子、激素和神经调质的调节。本研究旨在评估双侧腹膜后白色脂肪组织（rWAT）去神经支配（Dnx）对肥胖大鼠实验模型中骨矿物质代谢和重塑的影响。雄性 Wistar 大鼠在 18 周内分别用高脂肪饮食（HFD）或标准饮食（SD）喂养作为对照，并在第 14 周时进行 rWAT Dnx 或假手术。分析生化和激素参数、骨组织形态计量学、rWAT 和下丘脑蛋白和基因表达。HFD 组骨形成参数降低，血清和骨瘦素和 FGF23 增加，血清和下丘脑神经肽 Y（NPY）增加，血清 1,25-二羟维生素 D 和 PTH 降低。rWAT Dnx 后，骨标志物和组织形态计量学显示骨形成得到恢复，血清和下丘脑 NPY 降低，而瘦素水平没有改变。本研究表明，rWAT 的去神经支配通过优先减少 NPY 的神经激素作用改善肥胖大鼠的骨形成，强调了脂肪组织-脑-骨轴在肥胖症骨代谢控制中的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/40c332d8e7da/nutrients-15-03574-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/40c332d8e7da/nutrients-15-03574-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/9e079f0770c3/nutrients-15-03574-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/a2720aded4ad/nutrients-15-03574-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/e2543bf2bbab/nutrients-15-03574-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/5d34d2563bd0/nutrients-15-03574-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/5f479c8a8aab/nutrients-15-03574-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/8b9c41e4b13a/nutrients-15-03574-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/88e8bb287439/nutrients-15-03574-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/5e00cb65d3bd/nutrients-15-03574-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d49/10458609/40c332d8e7da/nutrients-15-03574-g009.jpg

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本文引用的文献

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Eur J Endocrinol. 2022 Oct 26;187(6):743-750. doi: 10.1530/EJE-22-0530. Print 2022 Dec 1.
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The Effect of a Sustained High-Fat Diet on the Metabolism of White and Brown Adipose Tissue and Its Impact on Insulin Resistance: A Selected Time Point Cross-Sectional Study.高脂肪饮食对白色和棕色脂肪组织代谢的影响及其对胰岛素抵抗的影响：一个选定的时间点横断面研究。
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