Cognetti F, Carlini P, Pinnarò P, Ruggeri E M, Caporali C
Oncology. 1986;43(5):292-4. doi: 10.1159/000226385.
In two previous consecutive studies on antiemetic combination of metoclopramide and dexamethasone was found to be very active against nausea and vomiting induced by cisplatin (DDP; 50 mg/m2) alone or in combination with other cytotoxic emetogenic drugs. In the present study the activity of the same antiemetic combination has been followed in 18 patients during subsequent DDP courses. Twelve out of 18 patients (67%) had a complete control of the side effect after the first course of chemotherapy. No statistically significant differences were found as regards the intensity of nausea and vomiting, the patients' overall opinions and preference and the emesis duration. In conclusion this antiemetic combination can guarantee a high degree and long-term control of DDP-induced emesis at a dose of 50 mg/m2 given alone or in combination.
在前两项连续研究中，发现胃复安和地塞米松的联合止吐方案对顺铂（DDP；50mg/m²）单独使用或与其他细胞毒性致吐药物联合使用所引起的恶心和呕吐非常有效。在本研究中，对18例患者在后续顺铂疗程中使用同一止吐联合方案的效果进行了跟踪。18例患者中有12例（67%）在第一个化疗疗程后副作用得到完全控制。在恶心和呕吐的强度、患者的总体意见和偏好以及呕吐持续时间方面，未发现统计学上的显著差异。总之，这种止吐联合方案能够保证在单独使用或联合使用50mg/m²剂量的顺铂时，对顺铂引起的呕吐实现高度且长期的控制。
