Dubrovskii Alexey V, Berezhnov Alexey V, Kim Aleksandr L, Tikhonenko Sergey A
Institute of Theoretical and Experimental Biophysics Russian Academy of Science, 3, Institutskaya Str., 142290 Pushchino, Moscow Region, Russia.
Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Moscow Region, Russia.
Polymers (Basel). 2023 Aug 8;15(16):3330. doi: 10.3390/polym15163330.
There are many studies devoted to the application of polyelectrolyte microcapsules (PMC) in various fields; however, there are significantly fewer studies devoted to the study of the polyelectrolyte microcapsules themselves. The study examined the mutual arrangement of the polyelectrolytes in 13-layered PMC capsules composed of (PAH/PSS)PAH. The research showed that different layers of the polyelectrolyte microcapsules dissociate equally, as in the case of 13-layered PMC capsules composed of (PAH/PSS)PAH with a well-defined shell, and in the case of 7-layered PMC capsules composed of (PAH/PSS)PAH, where the shell is absent. The study showed that polyallylamine layers labeled with FITC migrate to the periphery of the microcapsule regardless of the number of layers. This is due to an increase in osmotic pressure caused by the rapid flow of ions from the interior of the microcapsule into the surrounding solution. In addition, FITC-polyallylamine has a lower charge density and less interaction with polystyrene sulfonate in the structure of the microcapsule. Meanwhile, the hydrophilicity of FITC-polyallylamine does not change or decreases slightly. The results suggest that this effect promotes the migration of labeled polyallylamine to a more hydrophilic region of the microcapsule, towards its periphery.
有许多研究致力于聚电解质微胶囊（PMC）在各个领域的应用；然而，专门研究聚电解质微胶囊本身的研究却少得多。该研究考察了由（PAH/PSS）PAH组成的13层PMC胶囊中聚电解质的相互排列。研究表明，聚电解质微胶囊的不同层解离程度相同，例如在由具有明确壳层的（PAH/PSS）PAH组成的13层PMC胶囊中，以及在由（PAH/PSS）PAH组成的无壳层的7层PMC胶囊中。研究表明，用异硫氰酸荧光素（FITC）标记的聚烯丙胺层无论层数多少都会迁移到微胶囊的外围。这是由于离子从微胶囊内部快速流入周围溶液导致渗透压增加所致。此外，FITC - 聚烯丙胺的电荷密度较低，与微胶囊结构中的聚苯乙烯磺酸盐相互作用较少。同时，FITC - 聚烯丙胺的亲水性不变或略有降低。结果表明，这种效应促进了标记的聚烯丙胺向微胶囊更亲水的区域迁移，即向其外围迁移。
