Li Ruihan, Han Aojing, Hu Qilin, Liang Wei
School of Public Health, Wuhan University, Wuhan, P.R. China.
J Pediatr Endocrinol Metab. 2023 Aug 28;36(10):909-916. doi: 10.1515/jpem-2023-0183. Print 2023 Oct 26.
We aimed to explore the associations of neonatal hypocalcemia with neonatal vitamin D deficiency and maternal vitamin D deficiency. A comprehensive systematic literature search using PubMed and web of science was performed for relevant articles from inception to February 17th, 2023. We used odds ratio (OR) and 95 % confidence interval (CI) as effect sizes for our meta-analysis. Publication bias was evaluated using funnel plot, Begg's test, and Egger regression test. All the statistical analyses were performed using Stata 14.0. A total of 11 studies were included and analyzed, including 452 newborns with hypocalcemia and 2,599 newborns with normal serum calcium level. Our research results revealed that vitamin D deficiency in newborns may be related to the higher prevalence of hypocalcemia (OR: 2.87, 95 % CI: 1.17-7.04). In addition, maternal vitamin D deficiency might also be a risk factor for neonatal hypocalcemia (OR: 7.83, 95 % CI: 3.62-16.92). There was a significant correlation between vitamin D deficiency and neonatal hypocalcemia.This meta-analysis indicates that newborns with vitamin D deficiency have a higher risk of hypocalcemia, and maternal vitamin D level play a crucial role in this association. Vitamin D supplementation may have a positive effect in reducing the prevalence of neonatal hypocalcemia.
我们旨在探讨新生儿低钙血症与新生儿维生素D缺乏及母亲维生素D缺乏之间的关联。使用PubMed和科学网对从创刊至2023年2月17日的相关文章进行了全面的系统文献检索。我们使用比值比（OR）和95%置信区间（CI）作为荟萃分析的效应量。使用漏斗图、Begg检验和Egger回归检验评估发表偏倚。所有统计分析均使用Stata 14.0进行。共纳入并分析了11项研究，包括452例低钙血症新生儿和2599例血清钙水平正常的新生儿。我们的研究结果显示，新生儿维生素D缺乏可能与低钙血症的较高患病率相关（OR：2.87，95%CI：1.17 - 7.04）。此外，母亲维生素D缺乏也可能是新生儿低钙血症的一个危险因素（OR：7.83，95%CI：3.62 - 16.92）。维生素D缺乏与新生儿低钙血症之间存在显著相关性。这项荟萃分析表明，维生素D缺乏的新生儿患低钙血症的风险更高，并且母亲的维生素D水平在这种关联中起着关键作用。补充维生素D可能对降低新生儿低钙血症的患病率有积极作用。
