Department of Psychiatry and Behavioral Medicine, Center for AIDS Intervention Research, Medical College of Wisconsin, 2071 North Summit Avenue, Milwaukee, WI, 53202, USA.
Department of Health Promotion and Behavioral Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.
Cancer Causes Control. 2024 Jan;35(1):161-166. doi: 10.1007/s10552-023-01775-y. Epub 2023 Aug 26.
Self-sampling is increasingly being used in screening programs, yet no studies to date have examined the impact of bodily characteristics on self-sampling experiences. Our objective was to assess whether body mass index (BMI) and physical disability were associated with anal self-sampling difficulty.
We recruited sexual minority men (SMM) and trans persons in Milwaukee, Wisconsin to participate in an anal cancer screening study. Between January 2020 and August 2022, 240 participants were randomized to a home (n = 120) or clinic (n = 120) screening arm. Home participants received a mailed at-home anal self-sampling kit and were asked to attend a baseline clinic visit where biometric measurements were collected. Participants were asked to complete a survey about their experience with the kit. This research utilized data from participants who used the at-home kit and completed a baseline clinic visit and post-swab survey (n = 82). We assessed the impact of BMI and physical disability on reported body or swab positioning difficulty.
Most participants reported no or little difficulty with body positioning (90.3%) or swab positioning (82.9%). Higher BMI was significantly associated with greater reported difficulty with body positioning (aOR = 1.10, 95% CI 1.003-1.20, p = 0.04) and swab positioning (aOR = 1.11, 95% CI 1.02-1.20, p = 0.01). Although not significant, participants who said body positioning was difficult had 2.79 higher odds of having a physical disability. Specimen adequacy did not differ by BMI category (p = 0.76) or physical disability (p = 0.88).
Anal self-sampling may be a viable option to reach obese persons who may be more likely to avoid screening due to weight-related barriers.
自我采样在筛查项目中越来越多地被使用，但迄今为止尚无研究探讨身体特征对自我采样体验的影响。我们的目的是评估身体质量指数（BMI）和身体残疾是否与肛门自我采样难度相关。
我们招募了密尔沃基市的性少数群体男性（SMM）和跨性别者参加肛门癌筛查研究。在 2020 年 1 月至 2022 年 8 月期间，240 名参与者被随机分配到家庭（n=120）或诊所（n=120）筛查组。家庭组参与者收到了邮寄的家庭肛门自我采样试剂盒，并被要求参加基线诊所就诊，在此期间收集了生物特征测量值。参与者被要求完成一份关于他们使用试剂盒的体验的调查。本研究利用了使用家庭试剂盒并完成基线诊所就诊和采样后调查的参与者的数据（n=82）。我们评估了 BMI 和身体残疾对报告的身体或采样器定位困难的影响。
大多数参与者报告身体定位（90.3%）或采样器定位（82.9%）没有或几乎没有困难。较高的 BMI 与身体定位（优势比[aOR] = 1.10，95%置信区间[CI] 1.003-1.20，p=0.04）和采样器定位（aOR = 1.11，95%CI 1.02-1.20，p=0.01）困难显著相关。虽然不显著，但报告身体定位困难的参与者的身体残疾的可能性高出 2.79 倍。样本充足性不因 BMI 类别（p=0.76）或身体残疾（p=0.88）而有所不同。
肛门自我采样可能是一种可行的选择，可以接触到可能由于与体重相关的障碍而更有可能避免筛查的肥胖人群。
