Bhat R
Pediatrics. 1986 Nov;78(5):866-70.
Vitamin E is being used as an antioxidant in preterm neonates in an attempt to decrease the severity of retinopathy of prematurity. However, its efficacy may depend on many factors, a major one being its concentration in the retina. There is very little information available on the alpha-tocopherol levels in the human eye tissue. The present study was carried out to determine the total alpha-tocopherol levels in the retina, choroid, and vitreous and to compare the retinal levels with the serum levels obtained at the time of death. Thirteen whole eye donations were available during the past 22 months for the study. The data from this small number of cases showed that retinal levels of alpha-tocopherol were higher than choroidal and vitreal levels; higher serum levels were associated with higher retinal levels; and both serum and retinal alpha-tocopherol levels were lower in the unsupplemented (group A) infants. Further studies on pharmacokinetics of vitamin E in human newborns and its distribution are needed.
维生素E正被用于早产儿，作为一种抗氧化剂，试图降低早产儿视网膜病变的严重程度。然而，其疗效可能取决于许多因素，其中一个主要因素是其在视网膜中的浓度。关于人眼组织中α-生育酚水平的信息非常少。本研究旨在测定视网膜、脉络膜和玻璃体中的总α-生育酚水平，并将视网膜水平与死亡时获得的血清水平进行比较。在过去22个月中，有13例全眼球捐赠用于该研究。这少量病例的数据表明，视网膜中的α-生育酚水平高于脉络膜和玻璃体水平；血清水平较高与视网膜水平较高相关；未补充维生素E（A组）婴儿的血清和视网膜α-生育酚水平均较低。需要进一步研究维生素E在人类新生儿中的药代动力学及其分布情况。
