肝细胞对亚洲糖蛋白的摄取：免疫荧光显微镜检查
Asialoprotein uptake by liver cells: immunofluorescence microscopy.
作者信息
LeBouton A V, Lippman G
出版信息
Experientia. 1979 Mar 15;35(3):392-4. doi: 10.1007/BF01964372.
PMID:376333
Abstract
Uptake of asialoproteins by hepatocytes causes a change in the intracellular pattern of immunofluorescence. Control cells display a peripheral fluorescence which probably represents nascent proteins. Dark nonfluorescent areas, that presumably contain glycogen, are located around the nucleus. In contrast, liver cells from rats injected with asialoproteins display a pancytoplasmic fluorescence due to an influx of endocytotic vesicles.
摘要
肝细胞摄取去唾液酸糖蛋白会导致细胞内免疫荧光模式发生变化。对照细胞呈现外周荧光，这可能代表新生蛋白质。推测含有糖原的深色无荧光区域位于细胞核周围。相比之下，注射去唾液酸糖蛋白的大鼠的肝细胞由于内吞小泡的流入而呈现全细胞质荧光。
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