Ebbesen Brian D, Giordano Rocco, Valera-Calero Juan Antonio, Hedegaard Jakob Nebeling, Fernández-de-Las-Peñas César, Arendt-Nielsen Lars
Center for Neuroplasticity and Pain, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark; Department of Gastroenterology & Hepatology, Mech-Sense, Clinical Institute, Aalborg University Hospital, Aalborg, Denmark.
Center for Neuroplasticity and Pain, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark.
J Pain. 2024 Jan;25(1):1-11. doi: 10.1016/j.jpain.2023.08.011. Epub 2023 Aug 24.
This survey investigated the prevalence of de novo widespread musculoskeletal post-COVID pain and risk factors for its development in nonhospitalized COVID-19 survivors. A nationwide exploratory cross-sectional study was conducted, including a cohort of 593,741 Danish residents who had suffered from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from March 2020 to December 2021. A questionnaire was distributed to the Danish population via the digital mail system (e-Boks). Self-reported demographic data, previous medical comorbidities (diagnosed), socioeconomic data, time of infection, prior chronic pain conditions (diagnosed), development of de novo widespread pain after infection, pain medication, and pain intensity information were collected. Responders consisted of 130,443 nonhospitalized participants (58.2% women; mean age: 50.2 years). At a mean of 14.4 (standard deviation 6.0) months after infection, 6,875 (5.3%) patients reported the presence of de novo widespread musculoskeletal post-COVID pain. Almost 75% of the patients reported a moderate to severe intensity of the pain. In conclusion, de novo widespread post-COVID pain was present in 5.3% of nonhospitalized COVID-19 survivors 1 year after infection (14.4 ± 6.0 months). Older age, female sex, higher BMI, and history of migraine, whiplash, stress, type-2 diabetes, neurological disorders, and lower socioeconomic status were risk factors associated with the development of de novo widespread post-COVID pain in nonhospitalized patients. As de novo widespread pain is considered a sign of sensitization, this group will require specialized pain management attention. PERSPECTIVE: This article presents de novo widespread post-COVID pain prevalence in a cohort of 130,443 citizens infected with COVID-19. The study identifies potential risk factors associated with the development of these new pain symptoms. The results may increase focus on this patient group and potentially help identify predictors for postinfection pain development.
这项调查研究了新冠病毒感染康复后新出现的广泛性肌肉骨骼疼痛的患病率及其在非住院新冠病毒感染者中的发病风险因素。开展了一项全国性的探索性横断面研究，研究对象为2020年3月至2021年12月期间感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的593,741名丹麦居民。通过数字邮件系统（e-Boks）向丹麦民众发放了调查问卷。收集了自我报告的人口统计学数据、既往合并症（已确诊）、社会经济数据、感染时间、既往慢性疼痛状况（已确诊）、感染后新出现的广泛性疼痛情况、止痛药物及疼痛强度信息。应答者包括130,443名非住院参与者（女性占58.2%；平均年龄：50.2岁）。在感染后平均14.4（标准差6.0）个月时，6,875名（5.3%）患者报告出现了新冠病毒感染康复后新出现的广泛性肌肉骨骼疼痛。近75%的患者报告疼痛强度为中度至重度。总之，感染1年后（14.4±6.0个月），5.3%的非住院新冠病毒感染者出现了新冠病毒感染康复后新出现的广泛性疼痛。年龄较大、女性、体重指数较高、有偏头痛、挥鞭样损伤、压力、2型糖尿病、神经系统疾病史以及社会经济地位较低是与非住院患者出现新冠病毒感染康复后新出现的广泛性疼痛相关的风险因素。由于新出现的广泛性疼痛被认为是敏化的迹象，这一群体需要专门的疼痛管理关注。观点：本文介绍了130,443名感染新冠病毒的公民中新冠病毒感染康复后新出现的广泛性疼痛的患病率。该研究确定了与这些新疼痛症状发生相关的潜在风险因素。研究结果可能会增加对这一患者群体的关注，并有可能有助于识别感染后疼痛发生的预测因素。
