Donders Institute for Brain, Cognition and Behaviour and Radboudumc Center of Expertise on Rare Congenital Developmental Disorders, Radboud University, Nijmegen, The Netherlands; Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands.
Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands; Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Handb Clin Neurol. 2023;197:65-73. doi: 10.1016/B978-0-12-821375-9.00007-4.
Impulsive and aggressive behaviors along with intellectual disabilities often manifest in the context of genetic disorders and are a persisting challenge to professionals in the forensic psychiatric and psychological setting. The following chapter comprises an overview of relevant factors in the gene-context-behavior interaction such as monoamine oxidase A activity and specific epileptic phenomena. It presents several examples of monogenetic disorders with behaviors from the aggression spectrum and summarizes emerging strategies for treatment and clinical management thereof. The final part focuses on challenges and future developments in this field with relevance for the judicial and forensic systems. It is concluded that the relationship between a genetic syndrome and forensically relevant and/or violent behaviors should typically be addressed within a multidisciplinary framework that also includes the application of modern genetic techniques.
冲动和攻击行为以及智力障碍常常在遗传疾病的背景下表现出来，这对法医精神病学和心理学领域的专业人员来说是一个持续的挑战。以下章节概述了基因-情境-行为相互作用中的相关因素，如单胺氧化酶 A 活性和特定的癫痫现象。它介绍了几种具有攻击性谱行为的单基因疾病的例子，并总结了新兴的治疗和临床管理策略。最后一部分侧重于该领域对司法和法医系统具有相关性的挑战和未来发展。结论是，遗传综合征与法证相关和/或暴力行为之间的关系通常应在一个多学科框架内解决，其中还包括现代遗传技术的应用。
