Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, Weifang 261031, China; Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang 261031, China; Department of Pathology, Affiliated Hospital of Weifang Medical University, Weifang 261031, China.
Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, Weifang 261031, China; Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang 261031, China.
Biomed Pharmacother. 2023 Oct;166:115344. doi: 10.1016/j.biopha.2023.115344. Epub 2023 Aug 25.
The Wnt signaling system is a critical pathway that regulates embryonic development and adult homeostasis. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or Frizzled receptors. SFRPs can act as anti-Wnt agents and suppress cancer growth by blocking the action of Wnt ligands. However, SFRPs are often silenced by promoter methylation in cancer cells, resulting in hyperactivation of the Wnt pathway. Epigenetic modifiers can reverse this silencing and restore SFRPs expression. Despite the potential of SFRPs as a therapeutic target, the effects of SFRPs on tumor development remain unclear. Therefore, a review of the expression of various members of the SFRPs family in different cancers and their potential as therapeutic targets is warranted. This review aims to summarize the current knowledge of SFRPs in cancer, focusing on their expression patterns and their potential as novel therapeutic targets.
Wnt 信号通路是一个关键的途径，调节胚胎发育和成人的内稳态。分泌卷曲相关蛋白（SFRPs）是 Wnt 信号的细胞外抑制剂，通过直接与 Wnt 配体或卷曲受体结合发挥作用。SFRPs 可以作为抗 Wnt 因子，通过阻断 Wnt 配体的作用来抑制肿瘤生长。然而，SFRPs 通常在癌细胞中因启动子甲基化而沉默，导致 Wnt 通路的过度激活。表观遗传修饰物可以逆转这种沉默并恢复 SFRPs 的表达。尽管 SFRPs 作为治疗靶点具有潜力，但 SFRPs 对肿瘤发展的影响仍不清楚。因此，有必要对 SFRPs 家族的不同成员在不同癌症中的表达及其作为治疗靶点的潜力进行综述。本综述旨在总结 SFRPs 在癌症中的研究现状，重点关注其表达模式及其作为新型治疗靶点的潜力。
