Furtado-Alle Lupe, Tureck Luciane V, de Oliveira Carolina S, Hortega João V M, Souza Ricardo L R
Postgraduate Program in Genetics, Department of Genetics, Universidade Federal do Paraná UFPR, PR, Brazil.
Postgraduate Program in Genetics, Department of Genetics, Universidade Federal do Paraná UFPR, PR, Brazil.
Chem Biol Interact. 2023 Sep 25;383:110680. doi: 10.1016/j.cbi.2023.110680. Epub 2023 Aug 25.
Butyrylcholinesterase (BChE), an enzyme primarily found in the liver, plasma, and brain, has been recognized for its role in the hydrolysis of choline esters. Recent studies have shed light on its involvement in lipid metabolism, revealing its potential as a crucial player in maintaining lipid homeostasis. However, the interactions between external factors and BChE activity in lipid metabolic pathways remain a complex subject of study. This review summarizes the current knowledge regarding BChE activity and lipid metabolism and seeks to clarify the nature of this relationship as causal or consequential. Evidence supports the role of BChE in energy homeostasis disruption, such as obesity and related metabolic disorders, where it exhibits lipolytic activity and mediates fatty acid use and storage. The unexpected functions of BChE in lipoprotein synthesis and the impact of polymorphic variants of the BCHE gene suggest a central role in lipid metabolism; however, further investigation is needed to confirm and describe these functions, especially considering the metabolic context. Furthermore, exploring therapeutic interventions in lipid metabolism disorders contributes to elucidating their implications on BChE activity, but attention to the metabolic status and genotypes as possible factors in this interaction is needed. In summary, further research in this field holds promise for improving our understanding of the complex interplay between BChE and lipid metabolism, and its potential clinical applications. However, the available data corroborate the dual role of BChE activity, both as a critical responsive element to metabolic challenges and as a predisposition factor to metabolic diseases.
丁酰胆碱酯酶（BChE）是一种主要存在于肝脏、血浆和大脑中的酶，其在胆碱酯水解中的作用已得到认可。最近的研究揭示了它在脂质代谢中的参与情况，显示出它在维持脂质稳态方面作为关键参与者的潜力。然而，外部因素与脂质代谢途径中BChE活性之间的相互作用仍然是一个复杂的研究课题。本综述总结了关于BChE活性和脂质代谢的现有知识，并试图阐明这种关系是因果关系还是后果关系。有证据支持BChE在能量稳态破坏（如肥胖和相关代谢紊乱）中的作用，在这些情况下它表现出脂解活性并介导脂肪酸的利用和储存。BChE在脂蛋白合成中的意外功能以及BCHE基因多态性变体的影响表明其在脂质代谢中起核心作用；然而，需要进一步研究来证实和描述这些功能，特别是考虑到代谢背景。此外，探索脂质代谢紊乱的治疗干预有助于阐明它们对BChE活性的影响，但需要关注代谢状态和基因型作为这种相互作用中可能的因素。总之，该领域的进一步研究有望增进我们对BChE与脂质代谢之间复杂相互作用及其潜在临床应用的理解。然而，现有数据证实了BChE活性的双重作用，既是对代谢挑战的关键反应元件，也是代谢疾病的易患因素。
