Deen Laura, Clark Alice, Hougaard Karin Sørig, Petersen Kajsa Ugelvig, Frederiksen Marie, Wise Lauren A, Wesselink Amelia K, Meyer Harald William, Bonde Jens Peter, Tøttenborg Sandra Søgaard
Department of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, Denmark; Department of Public Health, The Faculty of Health Sciences, University of Copenhagen, Denmark.
Real World Science, Novo Nordisk, Denmark.
Environ Res. 2023 Nov 15;237(Pt 2):117000. doi: 10.1016/j.envres.2023.117000. Epub 2023 Aug 25.
Previous research indicates an association between higher-chlorinated polychlorinated biphenyls (PCBs) and type 2 diabetes (T2D). However, less is known about the extent to which PCB exposure in indoor air, composed primarily of lower-chlorinated PCBs, affects T2D risk. We assessed the association between indoor air exposure to PCBs in residential buildings and T2D incidence.
The register-based 'Health Effects of PCBs in Indoor Air' (HESPAIR) cohort comprises 51,921 Danish residents of two residential areas with apartments built with and without PCB-containing materials (reference apartments). We assessed exposure status by combining register-based information on relocation history with extrapolated values of exposure based on PCB-measurements in indoor air from subsets of the apartments. T2D cases were identified in the Danish registers during 1977-2018. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression analyses with time-varying exposure.
We identified 2737 incident T2D cases during the follow-up. Exposure to ≥3300 ng/m PCB × year (3rd tertile of PCB) was associated with higher risk of T2D (HR 1.15, 95% CI 1.02-1.30) compared with exposure to <300 ng/m PCB × year (reference). However, among individuals with lower cumulated PCB, the risk was similar to residents with exposure <300 ng/m PCB × year (300-899 ng/m PCB × year: HR 0.98, 95% CI 0.87-1.11; 900-3299 ng/m PCB × year: HR 0.96, 95% CI 0.83-1.10).
We observed a marginally higher risk of T2D, but there was no evidence of an exposure-response relationship. The results should be interpreted with caution until confirmed in other independent studies of PCB exposure in indoor air.
先前的研究表明，高氯多氯联苯（PCBs）与2型糖尿病（T2D）之间存在关联。然而，对于主要由低氯多氯联苯组成的室内空气中多氯联苯暴露对T2D风险的影响程度，人们了解较少。我们评估了住宅建筑室内空气中多氯联苯暴露与T2D发病率之间的关联。
基于登记的“室内空气中多氯联苯的健康影响”（HESPAIR）队列包括51921名丹麦两个居民区的居民，这些居民区的公寓有的是用含多氯联苯材料建造的，有的则不是（对照公寓）。我们通过将基于登记的搬迁历史信息与根据部分公寓室内空气中多氯联苯测量值推算出的暴露值相结合来评估暴露状况。1977年至2018年期间在丹麦登记册中确定T2D病例。我们使用具有时间变化暴露的Cox回归分析估计调整后的风险比（HR）和95%置信区间（CI）。
在随访期间，我们确定了2737例T2D新发病例。与每年暴露于<300 ng/m³多氯联苯（对照）相比，每年暴露于≥3300 ng/m³多氯联苯（多氯联苯第三分位数）与更高的T2D风险相关（HR 1.15，95% CI 1.02 - 1.30）。然而，在累积多氯联苯含量较低的个体中，风险与每年暴露于<300 ng/m³多氯联苯的居民相似（每年300 - 899 ng/m³多氯联苯：HR 0.98，95% CI 0.87 - 1.11；每年900 - 3299 ng/m³多氯联苯：HR 0.96，95% CI 0.83 - 1.10）。
我们观察到T2D风险略高，但没有证据表明存在暴露-反应关系。在其他关于室内空气中多氯联苯暴露的独立研究得到证实之前，对这些结果的解释应谨慎。
