University Hospital Center Mostar, University of Mostar.
School of Medicine, University of Mostar.
Acta Med Okayama. 2023 Aug;77(4):395-405. doi: 10.18926/AMO/65750.
We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=-0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=-0.258, t=-2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=-0.247, p=0.019) and antipsychotic treatment duration (ρ=-0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia.
我们研究了血清肿瘤坏死因子-α（TNF-α）水平与精神病理症状、临床和社会人口学特征以及抗精神病药物治疗在精神分裂症患者中的关系。我们测量了 90 名精神分裂症患者和 90 名年龄、性别、吸烟状况和体重指数匹配的健康对照者的 TNF-α 水平。阳性和阴性综合征量表（PANSS）用于评估患者的精神病理学严重程度。患者和对照组之间的 TNF-α 水平无显著差异（p=0.736）。TNF-α 水平与总分、阳性、阴性、一般或综合 PANSS 评分均无相关性（均 p>0.05）。TNF-α 水平与 PANSS 认知因子呈显著负相关（ρ=-0.222，p=0.035）。分层回归分析确定认知因子是 TNF-α 水平的显著预测因子（β=-0.258，t=-2.257，p=0.027）。不同类型抗精神病药物治疗的患者之间的 TNF-α 水平无显著差异（p=0.596）。TNF-α 水平与发病年龄呈正相关（ρ=0.233，p=0.027），与病程呈负相关（ρ=-0.247，p=0.019），与抗精神病药物治疗时间呈负相关（ρ=-0.256，p=0.015）。这些结果表明，TNF-α可能参与精神分裂症的认知障碍，并且可能是精神分裂症的潜在临床状态标志物。
