Razdan A K, Fang V S, Rich B H, Britton H, Rosenfield R L
Fertil Steril. 1979 May;31(5):507-12. doi: 10.1016/s0015-0282(16)43994-4.
We undertook a pilot study to determine whether infusion of gonadotropin-releasing hormone (GnRH) might improve the distinction of hypogonadotropinism from the normal state and might permit gonadotropin deficiency to be diagnosed in the prepubertal child. Normal prepubertal and pubertal boys had a greater luteinizing hormone (LH) reaction (delta LH 54 +/- 15 [SD] ng/ml and 165 +/- 23 ng/ml, respectively) to a 4-hour infusion (100 microgram/hour) than to a 100-microgram bolus of GnRH (19 +/- 9 and 52 +/- 35 ng/ml). These augmented responses were observed in boys with delayed puberty, but not in apparently hypogonadotropic males greater than or equal to 12 years old. LH (delta LH 445 to 1602 ng/ml) and FSH (delta FSH 718 to 2112 ng/ml) surges were induced consistently by GnRH infusion only in normal, postmenarchial females. In all, of 13 hypopituitary cases classified as hypogonadotropic on the basis of a subnormal response to GnRH infusion, 31% had a normal response to the GnRH bolus (P = 0.05). Thus, GnRH infusion testing seems to improve the distinction of hypogonadotropic patients from normal individuals, including boys with delayed puberty.
我们进行了一项初步研究，以确定输注促性腺激素释放激素（GnRH）是否可能改善低促性腺激素性性腺功能减退与正常状态的区分，并是否可能使青春期前儿童的促性腺激素缺乏得以诊断。正常青春期前和青春期男孩对4小时输注（100微克/小时）的促黄体生成素（LH）反应（LH变化量分别为54±15[标准差]纳克/毫升和165±23纳克/毫升）大于对100微克GnRH推注的反应（分别为19±9和52±35纳克/毫升）。在青春期延迟的男孩中观察到了这些增强反应，但在12岁及以上明显低促性腺激素的男性中未观察到。仅在正常的初潮后女性中，GnRH输注持续诱导出LH（LH变化量为445至1602纳克/毫升）和FSH（FSH变化量为718至2112纳克/毫升）高峰。总共13例垂体功能减退病例，根据对GnRH输注反应低于正常而被分类为低促性腺激素性，其中31%对GnRH推注有正常反应（P = 0.05）。因此，GnRH输注试验似乎改善了低促性腺激素患者与正常个体（包括青春期延迟男孩）的区分。
