Murakami Daichi, Kimura Takahito, Kono Masamitsu, Sakai Akihiro, Suenaga Tomohiro, Hiraoka Masanobu, Sakatani Hideki, Ohtani Makiko, Suzuki Hiroyuki, Tokuhara Daisuke, Hotomi Muneki
Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan.
Sakai ENT Clinic, Kinokawa, Japan.
Front Pediatr. 2023 Aug 10;11:1199240. doi: 10.3389/fped.2023.1199240. eCollection 2023.
Sensorineural hearing loss associated with Kawasaki disease has been increasingly reported, but its etiology remains unclear. Most reported cases of sensorineural hearing loss associated with Kawasaki disease have been mild and reversible during acute or subacute phases. However, bilateral severe hearing loss as a complication of Kawasaki disease can cause delays in cognitive and speech development. A 4-year-old Japanese boy treated for Kawasaki disease had right-side moderate and left-side profound sensorineural hearing loss on the 141st day after onset of Kawasaki disease. Despite systemic steroid pulse treatment, hearing loss remained in both sides. After the recurrence of Kawasaki disease, hearing on the right side progressively worsened, meaning there was now severe hearing loss on both sides. Left cochlear implantation performed on the 1065th day after the onset of Kawasaki disease improved the patient's hearing and his ability to communicate. Sensorineural hearing loss associated with Kawasaki disease may progress over a long period and cause bilateral severe hearing loss, although past reports showed occurrence during acute or subacute phases. The clinical course of our patient suggests that intense inflammation caused by Kawasaki disease could be related to prolonged hearing loss. Cochlear implantation seems to be effective for sensorineural hearing loss associated with Kawasaki disease.
与川崎病相关的感音神经性听力损失的报道日益增多，但其病因仍不清楚。大多数报道的与川崎病相关的感音神经性听力损失病例在急性期或亚急性期为轻度且可逆。然而，作为川崎病的一种并发症，双侧严重听力损失会导致认知和言语发育迟缓。一名接受川崎病治疗的4岁日本男孩在川崎病发病后第141天出现右侧中度和左侧重度感音神经性听力损失。尽管进行了全身性类固醇脉冲治疗，但双侧听力损失仍持续存在。川崎病复发后，右侧听力逐渐恶化，即双侧均出现严重听力损失。在川崎病发病后第1065天进行的左侧人工耳蜗植入改善了患者的听力和沟通能力。与川崎病相关的感音神经性听力损失可能会在很长一段时间内进展并导致双侧严重听力损失，尽管过去的报道显示其发生在急性期或亚急性期。我们患者的临床病程表明，川崎病引起的强烈炎症可能与听力损失持续时间延长有关。人工耳蜗植入似乎对与川崎病相关的感音神经性听力损失有效。
