Bodmer Walter
Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, UK.
Department of Oncology, University of Oxford, Oxford, UK.
Immunother Adv. 2023 Aug 17;3(1):ltad014. doi: 10.1093/immadv/ltad014. eCollection 2023.
The discovery of the history of the HLA system is reviewed from the earliest attempts at cancer transfers between mice, through the discovery of the mouse H-2 system on mouse red blood cells, the discovery of HLA class II and II antigens by use of sera from multiparous women, to the resolution of the HLA and H-2 functions explained by the attachment of intra cellular peptides to the HLA antigen grooves on the cell surface. The study of the associations between HLA types and diseases forms the basis for the subsequent extensive study of the genetics of human complex disease and phenotypes by GWAS (Genome Wide Association Studies).
本文回顾了HLA系统的发现历程，从最早在小鼠间进行癌症转移的尝试，到在小鼠红细胞上发现小鼠H-2系统，再到通过使用经产妇血清发现HLA II类和I类抗原，直至通过细胞内肽段附着于细胞表面的HLA抗原凹槽来解释HLA和H-2的功能。对HLA类型与疾病之间关联的研究，构成了随后通过全基因组关联研究（GWAS）对人类复杂疾病和表型遗传学进行广泛研究的基础。
