使用涂有全氟磺酸离子交换膜的碳糊电极进行体内伏安记录：关于监测到抗坏血酸释放的更多证据。
In vivo voltammetric recording with nafion-coated carbon paste electrodes: additional evidence that ascorbic acid release is monitored.
作者信息
Mueller K
出版信息
Pharmacol Biochem Behav. 1986 Aug;25(2):325-8. doi: 10.1016/0091-3057(86)90003-1.
The response of nafion-coated carbon paste electrodes was studied in vitro and in vivo with linear sweep semidifferential voltammetry. In vitro nafion-coated electrodes were insensitive to ascorbic acid (AA) but were equally sensitive to dopamine (DA) as were the uncoated electrodes. In vivo (anterior caudate) nafion-coated electrodes recorded small, poorly defined peaks. However, nafion-coated electrodes were equally responsive to microinfusion of DA as observed with the uncoated electrodes. Nafion-coated electrodes were insensitive to micro-infusion of AA while uncoated electrodes showed a large response to AA. These data suggest that endogenous DA levels are below the sensitivity of carbon paste electrodes in caudate and that the endogenous peaks recorded with uncoated carbon paste electrodes reflect AA.
采用线性扫描半微分伏安法对涂有全氟磺酸离子交换膜的碳糊电极进行了体外和体内研究。体外实验中，涂有全氟磺酸离子交换膜的电极对维生素C（AA）不敏感，但对多巴胺（DA）的敏感性与未涂覆电极相同。在体内（尾状核前部），涂有全氟磺酸离子交换膜的电极记录到小的、不清晰的峰。然而，涂有全氟磺酸离子交换膜的电极对多巴胺微量注射的反应与未涂覆电极相同。涂有全氟磺酸离子交换膜的电极对维生素C微量注射不敏感，而未涂覆电极对维生素C有较大反应。这些数据表明，尾状核中内源性多巴胺水平低于碳糊电极的灵敏度，未涂覆碳糊电极记录到的内源性峰反映的是维生素C。
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