de Jong F H
Mol Cell Endocrinol. 1979 Jan;13(1):1-10. doi: 10.1016/0303-7207(79)90071-6.
Peripheral concentrations of follicle-stimulating hormone (FSH) in male as well as in female animals appear to be partly regulated by inhibin, a protein which is secreted by the gonads. The molecular structure of this substance is still unknown, and the mechanism(s) of its action on the pituitary or hypothalamic level is not clear. Much of the confusion about inhibin stems from the fact that no generally accepted definition of inhibin exists and that fundamentally different biological assay systems have been used by different groups. Therefore this short review starts with a discussion of the definition of inhibin and the assay principles. From the available information on the site of origin of the hormone it appears likely that inhibin is produced in the Sertoli cells of the testis and the granulosa cells of the ovary. The available data on the chemical nature of inhibin suggest that different principles, acting on different sites of the hypothalamic--pituitary axis, might be present in preparations with inhibin-like activity. Finally, with respect to the biological significance of inhibin, it seems that inhibin could play a more important role in the feedback regulation of FSH in the adult female than in the adult male animal.
在雄性和雌性动物中，促卵泡激素（FSH）的外周浓度似乎部分受抑制素调节，抑制素是一种由性腺分泌的蛋白质。这种物质的分子结构仍然未知，其在垂体或下丘脑水平的作用机制也不清楚。关于抑制素的许多困惑源于这样一个事实，即目前尚无被普遍接受的抑制素定义，而且不同研究小组使用了根本不同的生物检测系统。因此，这篇简短的综述首先讨论抑制素的定义和检测原理。根据有关该激素起源部位的现有信息，抑制素似乎是由睾丸的支持细胞和卵巢的颗粒细胞产生的。关于抑制素化学性质的现有数据表明，具有抑制素样活性的制剂中可能存在作用于下丘脑 - 垂体轴不同部位的不同原理。最后，关于抑制素的生物学意义，抑制素似乎在成年雌性动物中对FSH的反馈调节中比在成年雄性动物中发挥更重要的作用。
