Lamture Varsha Y, Lamture Yashwant R, Uke Punam
Department of Pharmacology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Department of Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2023 Jul 24;15(7):e42407. doi: 10.7759/cureus.42407. eCollection 2023 Jul.
Stevens-Johnson syndrome (SJS) is a dreaded hypersensitivity reaction and a rare immune disorder. We present a Stevens-Johnson syndrome induced by herbal kadha, which may be the first case. A ten-year-old boy presented with massive sloughing, redness, oedematous skin, an oral ulcer, and an inability to feed or drink for two days. The present symptoms started after 12 hours of consuming herbal Kadha, given by a private practitioner in clinics where he was treated for fever. After not responding to earlier treatment, the patient was referred to the present Institute. The patient had a history of seizure disorder and had been on tablet phenytoin for seven months with no history of adverse reactions to it. He was treated in the intensive care unit. Fortunately, he responded to treatment and recovered fully. He received treatment in the form of immunoglobulin and steroids. Phenytoin and herbal kadha were withdrawn, and Clobazam was continued. Natural herbal medicines can develop severe adverse effects. Physicians should remain aware that drug interactions can likely be seen with drugs with a narrow therapeutic index combined with herbal preparations. Clinicians should do more research on the interaction between herbal and prescription medications.
史蒂文斯-约翰逊综合征（SJS）是一种可怕的超敏反应，也是一种罕见的免疫疾病。我们报告了一例由草药卡德哈诱发的史蒂文斯-约翰逊综合征，这可能是首例。一名10岁男孩出现大量皮肤脱落、发红、皮肤水肿、口腔溃疡，且两天无法进食或饮水。目前这些症状在服用私人诊所医生为其治疗发热而开具的草药卡德哈12小时后开始出现。在对早期治疗无反应后，该患者被转诊至本研究所。该患者有癫痫病史，服用苯妥英钠片七个月，此前无不良反应史。他在重症监护病房接受治疗。幸运的是，他对治疗有反应并完全康复。他接受了免疫球蛋白和类固醇形式的治疗。停用了苯妥英钠和草药卡德哈，继续使用氯巴占。天然草药可能会产生严重的不良反应。医生应意识到，治疗指数窄的药物与草药制剂合用时可能会出现药物相互作用。临床医生应对草药与处方药之间的相互作用进行更多研究。
