Suda Toshikuni, Takahashi Morio, Katayama Yasumi, Soga Koichi, Kobori Ikuhiro, Kusano Yumi, Tamano Masaya
Division of Gastroenterology, Dokkyo Medical University Saitama Medical Center, Saitama 343-8555, Japan.
Division of Gastroenterology, Morio Clinic, Saitama 343-0808, Japan.
World J Clin Cases. 2023 Aug 16;11(23):5462-5467. doi: 10.12998/wjcc.v11.i23.5462.
We have previously demonstrated that the first wave of the coronavirus disease 2019 (COVID-19) pandemic caused exacerbations in ulcerative colitis (UC) patients, probably through psychological and physical stress. However, successive waves of the COVID-19 pandemic continuously followed the first. The effects of this chronic stress on the disease condition in UC patients are of interest.
To clarify the effect of chronic stress from COVID-19 on disease condition in patients aggravated after the first wave.
Our previous study investigated 289 consecutive UC outpatients treated in one center during March and April 2020, the period of the first wave of the COVID-19 pandemic. In this study, an identical group of 289 UC patients was evaluated using UC-disease activity index (UC-DAI), endoscopic mucosal appearance score, and Matts pathological grade scoring.
Of the 289 UC patients included in the study in 2020, 10 patients dropped out as of 2021 and another 11 patients dropped out as of 2022, making three groups for 2020, 2021 and 2022. No significant differences in characteristics were found among the three groups. UC-DAI scores had aggravated during the period of the first wave of the COVID-19 pandemic, but significantly recovered in 2021 and remained stable in 2022. Matts grade scores significantly recovered in 2021 from those in 2020 and remained stable in 2022.
Disease activity of UC patients recovered in 2021 and remained stable in 2022, aggravated by the stress of the first wave of COVID-19 in 2020 despite persistence of the pandemic.
我们之前已经证明，2019年冠状病毒病（COVID-19）大流行的第一波疫情导致溃疡性结肠炎（UC）患者病情加重，可能是通过心理和身体压力。然而，COVID-19大流行的后续波次不断接踵而至。这种慢性压力对UC患者疾病状况的影响令人关注。
阐明COVID-19带来的慢性压力对在第一波疫情后病情加重的患者疾病状况的影响。
我们之前的研究调查了2020年3月至4月（COVID-19大流行第一波期间）在一个中心接受治疗的289例连续性UC门诊患者。在本研究中，对同一组289例UC患者使用UC疾病活动指数（UC-DAI）、内镜黏膜外观评分和马茨病理分级评分进行评估。
在2020年纳入研究的289例UC患者中，截至2021年有10例退出，截至2022年又有11例退出，从而形成了2020年、2叭年和2022年三组。三组之间在特征方面未发现显著差异。UC-DAI评分在COVID-19大流行第一波期间有所加重，但在2021年显著恢复，并在2022年保持稳定。马茨分级评分在2021年较2020年显著恢复，并在2022年保持稳定。
UC患者的疾病活动在2021年恢复，并在2022年保持稳定，尽管疫情持续存在，但在2020年因COVID-19第一波疫情的压力而加重。
