Neuroscience Group of Antioquia, University of Antioquia, Medellin, Colombia.
University of Antioquia, Medellin, Colombia.
J Alzheimers Dis. 2023;95(3):1091-1106. doi: 10.3233/JAD-220941.
The SARS-CoV2 global pandemic impacted participants in the Alzheimer's Prevention Initiative (API) Autosomal Dominant Alzheimer's Disease (ADAD) clinical trial, who faced three stressors: 1) fear of developing dementia; 2) concerns about missing treatment; and 3) risk of SARS-CoV2 infection.
To describe the frequency of psychological disorders among the participants of the API ADAD Colombia clinical study, treated by a holistic mental health team during the COVID-19 pandemic. The extent of use of mental health team services was explored considering different risk factors, and users and non-users of these services were compared.
Participants had free and optional access to psychology and psychiatry services, outside of the study protocol. Descriptive statistics was used to analyze the frequency of the mental health difficulties. A multivariable logistic regression model has been used to assess associations with using this program.
66 participants were treated by the Mental Health Team from March 1, 2020, to December 31, 2020. Before and after the start of the pandemic, the most common psychological problems were anxiety (36.4% before, 63.6% after) and depression (34.8% before, 37.9% after). 70% of users assisted by psychology and 81.6% of those assisted by psychiatry felt that the services were useful for them. Female sex, depression, and anxiety before the pandemic were positively associated with being assisted by either psychology or psychiatry, while the association with hyperlipidemia was negative.
A holistic mental health program, carried out in the context of a study, could mitigate psychopathology during pandemics such as COVID-19.
SARS-CoV2 全球大流行影响了阿尔茨海默病预防倡议（API）常染色体显性阿尔茨海默病（ADAD）临床试验的参与者，他们面临着三个压力源：1）担心患上痴呆症；2）担心错过治疗；3）感染 SARS-CoV2 的风险。
描述在 COVID-19 大流行期间，由一个整体心理健康团队治疗的 API ADAD 哥伦比亚临床研究参与者的心理障碍频率。考虑到不同的风险因素，探讨了对心理健康团队服务的使用程度，并比较了使用者和非使用者。
参与者可以自由选择是否接受心理学和精神病学服务，这些服务不在研究方案之外。使用描述性统计分析心理健康困难的频率。使用多变量逻辑回归模型评估与使用该方案的关联。
2020 年 3 月 1 日至 2020 年 12 月 31 日，共有 66 名参与者接受了心理健康团队的治疗。在大流行开始前后，最常见的心理问题是焦虑（36.4%，36.4%）和抑郁（34.8%，37.9%）。接受心理学和精神病学治疗的患者中有 70%和 81.6%的人认为这些服务对他们有用。大流行前的女性、抑郁和焦虑与接受心理学或精神病学治疗呈正相关，而与血脂异常呈负相关。
在研究背景下开展的整体心理健康计划，可以减轻 COVID-19 等大流行期间的心理病理。
