Maurer A H, Millmond S H, Knight L C, Mesgarzadeh M, Siegel J A, Shuman C R, Adler L P, Greene G S, Malmud L S
Radiology. 1986 Oct;161(1):221-5. doi: 10.1148/radiology.161.1.3763871.
Indium-111 labeled leukocyte imaging was compared with three-phase skeletal scintigraphy as a means of determining whether osteomyelitis was complicating diabetic osteoarthropathy. Three-phase scintigraphy demonstrated increased activity in both infected and noninfected osteopathic bone, with a sensitivity of 75% and a specificity of 56% for osteomyelitis. Leukocyte imaging had the same sensitivity but was most helpful for excluding infection (specificity, 89%) when three-phase imaging could not. Abnormal leukocyte localization was seen at the primary site of infection in all cases within 4 hours after injection. Disadvantages of leukocyte imaging included long preparation time, low count rates resulting in poor spatial resolution, and absence of bone landmarks, which made it difficult to differentiate soft tissue from bone infection.
将铟 - 111标记的白细胞显像与三相骨闪烁显像进行比较，以此作为确定骨髓炎是否使糖尿病性骨关节病复杂化的一种方法。三相骨闪烁显像显示，感染性和非感染性骨病性骨的活性均增加，对骨髓炎的敏感性为75%，特异性为56%。白细胞显像具有相同的敏感性，但在三相显像无法排除感染时（特异性为89%），白细胞显像对于排除感染最有帮助。在注射后4小时内，所有病例在感染的原发部位均可见白细胞异常定位。白细胞显像的缺点包括准备时间长、计数率低导致空间分辨率差以及缺乏骨标志，这使得区分软组织感染和骨感染变得困难。
