用于合成烯丙基二氟化物的苄醇的双光氧化还原/镍催化脱水二氟烷基化反应
Dual Photoredox/Nickel-Catalyzed Dehydrative Difluoroalkylation of Benzyl Alcohols for the Synthesis of Allylic -Difluorides.
作者信息
Bai Yuyang, Cao Liping, Li Siyuan, Zhang Guang'an, Liu Yingguo, Zhao Fengqian, Wu Junliang
机构信息
Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450001, P. R. China.
Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China.
出版信息
Org Lett. 2023 Sep 8;25(35):6511-6516. doi: 10.1021/acs.orglett.3c02248. Epub 2023 Aug 28.
A photoredox/Lewis acid cooperative catalytic system has been developed for the construction of C-C bonds through the dehydrative difluoroalkylation of benzyl alcohols. A variety of allylic -difluorides could be obtained in moderate yields with good to excellent / selectivity. In addition, several control experiments have been explored, and a possible mechanism was proposed for this process.
已开发出一种光氧化还原/路易斯酸协同催化体系，用于通过苄醇的脱水二氟烷基化反应构建碳-碳键。可以中等产率获得多种烯丙基二氟化物，具有良好至优异的立体选择性。此外，还进行了一些对照实验，并提出了该过程可能的机理。
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