Scharffetter-Kochanek Karin, Wang Yongfang, Makrantonaki Evgenia, Crisan Diana, Wlaschek Meinhard, Geiger Hartmut, Maity Pallab
Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland.
Labor für experimentelle Dermatologie der Klinik für Dermatologie und Allergologie, Universität Ulm, Ulm, Deutschland.
Dermatologie (Heidelb). 2023 Sep;74(9):645-656. doi: 10.1007/s00105-023-05201-x. Epub 2023 Aug 28.
Cellular senescence is the main cause of skin and organ aging and is associated with a wide range of aging-related diseases.
To understand which senolytics, senomorphics, and cell-based therapies have been developed to alleviate and even rejuvenate skin aging and reduce cellular senescence.
Basic literature for the mode of action of senolytics and senomorphics and their clinical perspectives in daily routine are discussed.
Various causes lead to mitochondrial dysfunction and the activation of pro-aging signaling pathways, which eventually lead to cellular senescence with degradation of structural proteins of the dermal connective tissue and severe suppression of regenerative stem cell niches of the skin.
Depletion of senescent cells suppress skin aging and enforce rejuvenation of skin and other organs and their function. The removal of senescent cells by cells of the native immune system is severely disturbed during aging. Selected senolytics and senomorphics are approved and are already on the market.
细胞衰老为皮肤和器官衰老的主要原因，且与多种衰老相关疾病有关。
了解已开发出哪些衰老细胞溶解剂、衰老细胞形态调节剂及基于细胞的疗法来缓解甚至逆转皮肤衰老并减少细胞衰老。
讨论了衰老细胞溶解剂和衰老细胞形态调节剂作用方式的基础文献及其在日常临床中的应用前景。
多种原因导致线粒体功能障碍及促衰老信号通路激活，最终导致细胞衰老，伴有真皮结缔组织结构蛋白降解及皮肤再生干细胞微环境的严重抑制。
清除衰老细胞可抑制皮肤衰老，促进皮肤及其他器官的年轻化及其功能恢复。衰老过程中，天然免疫系统细胞清除衰老细胞的功能受到严重干扰。某些衰老细胞溶解剂和衰老细胞形态调节剂已获批准并已上市。
