Jilin Provincial Key Laboratory of Nutrition and Functional Food, Jilin University, 130062 Changchun, China.
College of Food Science and Engineering, Jilin University, 130062 Changchun, China.
J Agric Food Chem. 2023 Sep 13;71(36):13168-13180. doi: 10.1021/acs.jafc.3c03230. Epub 2023 Aug 28.
Impaired intestinal barrier function can impede the digestion and absorption of nutrients and cause a range of metabolic disorders, which are the main causes of intestinal disease. Evidence suggests that proper dietary protein intake can prevent and alleviate intestinal diseases. Egg white protein (EWP) has received considerable attention, because of its high protein digestibility and rich amino acid composition. Furthermore, bioactive peptides may have an increased repair effect due to their high degradation efficiency in the gut. In this study, we aimed to review the effects of EWP and its bioactive peptides on intestinal structural repair. The potential modulation mechanisms by which EWP and their peptides regulate the gut microbiota and intestinal barrier can be summarized as follows: (1) restoring the structure of the intestinal barrier to its intact form, (2) enhancing the intestinal immune system and alleviating the inflammatory response and oxidative damage, and (3) increasing the relative abundance of beneficial bacteria and metabolites. Further in-depth analysis of the coregulation of multiple signaling pathways by EWP is required, and the combined effects of these multiple mechanisms requires further evaluation in experimental models. Human trials can be considered to understand new directions for development.
肠道屏障功能受损会妨碍营养物质的消化和吸收，并导致一系列代谢紊乱，这是肠道疾病的主要原因。有证据表明，适当的膳食蛋白质摄入可以预防和缓解肠道疾病。蛋清蛋白 (EWP) 因其高蛋白消化率和丰富的氨基酸组成而受到广泛关注。此外，由于其在肠道中的高降解效率，生物活性肽可能具有增强的修复作用。在本研究中，我们旨在综述 EWP 及其生物活性肽对肠道结构修复的影响。EWP 及其肽调节肠道微生物群和肠道屏障的潜在调节机制可以概括为：（1）使肠道屏障结构恢复到完整形式，（2）增强肠道免疫系统，减轻炎症反应和氧化损伤，以及（3）增加有益细菌和代谢物的相对丰度。需要进一步深入分析 EWP 对多个信号通路的核心调控作用，并且需要在实验模型中进一步评估这些多种机制的联合作用。可以考虑进行人体试验，以了解新的发展方向。
