内源性血小板激活因子诱导豚鼠血栓形成及银杏叶提取物对其的抑制作用
Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig.
作者信息
Bourgain R H, Maes L, Andries R, Braquet P
出版信息
Prostaglandins. 1986 Jul;32(1):142-4. doi: 10.1016/0090-6980(86)90157-7.
The anti-thrombotic effects of specific paf-acether antagonist BN 52021 were compared to the effects of Ginkgo Biloba extracts A, B, (A + B), and C. Local superfusion of BN 52021 over an experimentally injured arterial segment embolizes an existent paf-acether induced platelet thrombus. When applied before paf-acether, BN 52021 prevents local thromboformation in this model. Applied intravenously, BN 52021 reduces local thromboformation in a significant way. As compared to this BN 52021 standard, only Ginkgo Biloba B and the (A + B)-mixture present major thromboreductive activity.
将特定的血小板激活因子拮抗剂BN 52021的抗血栓形成作用与银杏叶提取物A、B、（A + B）和C的作用进行了比较。在实验性损伤的动脉段局部灌注BN 52021可使现有的由血小板激活因子诱导的血小板血栓栓塞。在血小板激活因子之前应用时，BN 52021可防止该模型中局部血栓形成。静脉内应用时，BN 52021可显著减少局部血栓形成。与该BN 52021标准相比，只有银杏叶提取物B和（A + B）混合物具有主要的抗血栓形成活性。
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