Pompei G, Romani F, Nardini M, Zennaro R G, Canossi G
Radiol Med. 1986 Sep;72(9):632-6.
The authors report their experience in fibrinolytic therapy with Urokinase in acute myocardial infarction. There were 3 groups of treatment: 100 patients with intracoronary fibrinolytic therapy; 77 patients with peripheral venous fibrinolytic administration; 31 patients with conventional therapy. The 3 groups underwent, between 21 and 28 days after the acute event, a coronarographic examination to evaluate the persistence of patency of the vessels involved in the myocardial infarction. The short term results show that the fibrinolytic therapy (with the limitations due to the hemorrhagic complications associated with the use of Urokinase), especially via intracoronary, is significantly more useful and reliable than conventional therapy, which appears unsatisfactory. Therapeutic failures are probably due to diffuse atherosclerosis of the vessel and/or to the old age of the thrombus.
作者报告了他们使用尿激酶进行急性心肌梗死溶栓治疗的经验。有3组治疗：100例患者接受冠状动脉内溶栓治疗；77例患者接受外周静脉溶栓给药；31例患者接受传统治疗。在急性事件发生后的21至28天之间，这3组患者均接受了冠状动脉造影检查，以评估心肌梗死相关血管的通畅持续性。短期结果表明，溶栓治疗（由于使用尿激酶相关的出血并发症存在局限性），尤其是冠状动脉内溶栓，比传统治疗明显更有效且可靠，传统治疗似乎并不令人满意。治疗失败可能是由于血管弥漫性动脉粥样硬化和/或血栓形成时间较长。
