Department of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Boston University Alzheimer's Disease Research Center, Boston, MA, USA.
Neurobiol Aging. 2023 Nov;131:144-152. doi: 10.1016/j.neurobiolaging.2023.07.021. Epub 2023 Jul 20.
Majority of dementia research is conducted in non-Hispanic White participants despite a greater prevalence of dementia in other racial groups. To obtain a better understanding of biomarker presentation of Alzheimer's disease (AD) in the non-Hispanic White population, this study exclusively examined AD biomarker abnormalities in 85 Black and/or African American participants within the Alzheimer's Disease Neuroimaging Initiative (ADNI). Participants were classified by the ADNI into 3 clinical groups: cognitively normal, mild cognitive impairment, or dementia. Data examined included demographics, apolipoprotein E (APOE) ε4, cerebrospinal fluid (CSF) Aβ, CSF total tau (t-tau), CSF phosphorylated tau (p-tau), 3T magnetic resonance imaging (MRI), and measures of cognition and function. Analyses of variance and covariance showed lower cortical thickness in 5 of 7 selected MRI regions, lower hippocampal volume, greater volume of white matter hyperintensities, lower measures of cognition and function, lower measures of CSF Aβ, and greater measures of CSF t-tau and p-tau between clinical groups. Our findings confirmed greater AD biomarker abnormalities between clinical groups in this sample.
尽管其他种族群体的痴呆症发病率更高，但大多数痴呆症研究都是在非西班牙裔白人群体中进行的。为了更好地了解非西班牙裔白人群体中阿尔茨海默病（AD）的生物标志物表现，本研究仅在阿尔茨海默病神经影像学倡议（ADNI）中检查了 85 名黑人和/或非裔美国参与者的 AD 生物标志物异常。参与者根据 ADNI 被分为 3 个临床组：认知正常、轻度认知障碍或痴呆。检查的数据包括人口统计学、载脂蛋白 E（APOE）ε4、脑脊液（CSF）Aβ、CSF 总 tau（t-tau）、CSF 磷酸化 tau（p-tau）、3T 磁共振成像（MRI）以及认知和功能测量。方差和协方差分析显示，在 7 个选定的 MRI 区域中有 5 个区域的皮质厚度较低，海马体积较小，白质高信号体积较大，认知和功能测量值较低，CSF Aβ 测量值较低，CSF t-tau 和 p-tau 测量值较高。我们的研究结果证实了该样本中临床组之间存在更大的 AD 生物标志物异常。
