Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Via G. Salvemini 1, Perugia 06126, Italy.
Azienda Sanitaria Locale 1, Via XIV Settembre 79, Parco S. Margherita, Perugia 06121, Italy.
Res Vet Sci. 2023 Oct;163:104983. doi: 10.1016/j.rvsc.2023.104983. Epub 2023 Aug 15.
Mycoplasma infections are commonly found in the respiratory system of small ruminants; the species most commonly detected are Mycoplasma ovipneumoniae and Mycoplasma arginini, associated with the so-called "atypical non-progressive pneumonia". The pathogenic role of M. ovipneumoniae in pneumonia has been demonstrated in sheep but still needs to be verified in goats; on the other hand, the role of M. arginini in sheep is not well understood, while in goats seems to be of low pathogenic value. The present study aims to investigate the aetiology of pneumonia in sheep and goats that died from respiratory disease using anatomopathological, histopathological, and molecular investigations and to clarify the role of respiratory mycoplasmas by the association of molecular data with histopathological features. First, to better understand which histological changes are actually suggestive of atypical pneumonia in sheep and goats, the study identified the histological lesions significantly associated with Mycoplasma spp. infection. Then, the histological score of lesions considered suggestive of atypical pneumonia was used to estimate the pathogenicity of each mycoplasma detected. The results showed that M. ovipneumoniae and M. arginini (alone or in mixed infections) are pathogenic both in sheep, as well as in goats with similar histology and severity of lesions. Moreover, young animals were statistically more susceptible to M.ovipneumoniae and M. arginini infection than adults. Animals appeared more at risk to the development of M. ovipneumoniae and M. arginini infection in summer.
绵羊和山羊呼吸道疾病剖检、组织病理学和分子病原学调查
绵羊和山羊呼吸道疾病剖检、组织病理学和分子病原学调查
绵羊和山羊呼吸系统的支原体感染很常见；最常检测到的物种是绵羊肺炎支原体和精氨酸支原体，与所谓的“非典型进行性肺炎”有关。绵羊肺炎支原体在肺炎中的致病作用已在绵羊中得到证实，但仍需在山羊中得到验证；另一方面，精氨酸支原体在绵羊中的作用尚不清楚，而在山羊中似乎具有低致病性。本研究旨在使用解剖病理学、组织病理学和分子调查来调查因呼吸道疾病而死亡的绵羊和山羊肺炎的病因，并通过将分子数据与组织病理学特征相关联来阐明呼吸道支原体的作用。首先，为了更好地了解哪些组织学变化实际上提示绵羊和山羊的非典型肺炎，本研究确定了与支原体感染明显相关的组织学病变。然后，使用被认为提示非典型肺炎的病变的组织学评分来估计检测到的每种支原体的致病性。结果表明，绵羊和山羊的肺炎支原体和精氨酸支原体（单独或混合感染）均具有致病性，其组织学和病变严重程度相似。此外，与成年动物相比，年幼动物对绵羊肺炎支原体和精氨酸支原体感染的易感性更高。与夏季相比，动物更易发生绵羊肺炎支原体和精氨酸支原体感染。
