Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia.
The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, Queensland, Australia.
Psychiatry Res Neuroimaging. 2023 Oct;335:111707. doi: 10.1016/j.pscychresns.2023.111707. Epub 2023 Aug 22.
The current study aimed to validate entorhinal and transentorhinal cortical volumes measured by the automated segmentation tool Automatic Segmentation of Hippocampal Subfields (ASHS-T1). The study sample comprised 34 healthy controls (HCs), 37 individuals with amnestic mild cognitive impairment (aMCI), and 29 individuals with Alzheimer's disease (AD) dementia from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Entorhinal and transentorhinal cortical volumes were assessed using ASHS-T1, manual segmentation, as well as a widely used automated segmentation tool, FreeSurfer v6.0.1. Mean differences, intraclass correlation coefficients, and Bland-Altman plots were computed. ASHS-T1 tended to underestimate entorhinal and transentorhinal cortical volumes relative to manual segmentation and FreeSurfer. There was variable consistency and low agreement between ASHS-T1 and manual segmentation volumes. There was low-to-moderate consistency and low agreement between ASHS-T1 and FreeSurfer volumes. There was a trend toward higher consistency and agreement for the entorhinal cortex in the aMCI and AD groups compared to the HC group. Despite the differences in volume measurements, ASHS-T1 was sensitive to entorhinal and transentorhinal cortical atrophy in both early and late disease stages. Based on the current study, ASHS-T1 appears to be a promising tool for automated entorhinal and transentorhinal cortical volume measurement in individuals with likely underlying AD.
本研究旨在验证由自动分割工具自动海马亚区分割（ASHS-T1）测量的内嗅皮质和穿通内嗅皮质体积。研究样本包括来自阿尔茨海默病神经影像学倡议（ADNI）数据库的 34 名健康对照（HC）、37 名有遗忘型轻度认知障碍（aMCI）的个体和 29 名患有阿尔茨海默病（AD）痴呆的个体。使用 ASHS-T1、手动分割以及广泛使用的自动分割工具 FreeSurfer v6.0.1 评估内嗅皮质和穿通内嗅皮质体积。计算了均值差异、组内相关系数和 Bland-Altman 图。ASHS-T1 倾向于低估相对于手动分割和 FreeSurfer 的内嗅皮质和穿通内嗅皮质体积。ASHS-T1 与手动分割体积之间的一致性存在差异，且一致性低。ASHS-T1 与 FreeSurfer 体积之间的一致性和一致性低。与 HC 组相比，在 aMCI 和 AD 组中，ASHS-T1 与手动分割体积之间的一致性和一致性呈上升趋势。尽管体积测量存在差异，但 ASHS-T1 对内嗅皮质和穿通内嗅皮质在早期和晚期疾病阶段的萎缩敏感。基于本研究，ASHS-T1 似乎是一种有前途的工具，可用于自动测量 AD 潜在患者的内嗅皮质和穿通内嗅皮质体积。
