Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China.
Am J Reprod Immunol. 2023 Sep;90(3):e13755. doi: 10.1111/aji.13755.
The role of decidual natural killer (dNK) cells in maintaining immune tolerance at the maternal-fetal interface during pregnancy is a significant topic in reproductive health. Immune tolerance is essential for a successful pregnancy and involves a complex immune response involving various immune cells and molecules. DNK cells comprise the largest population of lymphocyte subsets found in the decidua and play important roles in maintaining immune tolerance. These cells exert multiple functions to maintain homeostasis of the decidual microenvironment, including modulation of trophoblast invasion, promotion of fetal development, regulation of endometrial decidualization and spiral artery remodeling. DNK cells can also be divided into different subsets based on their functions as NK , NK , and NK cells. However, the relationship between dNK cells function and pregnancy outcomes is complex and poorly understood. In this review, we will focus on the physiological role of dNK cells during pregnancy and highlight the potential role in pathological pregnancies and therapeutic approaches.
在妊娠期间，蜕膜自然杀伤 (dNK) 细胞在维持母体-胎儿界面的免疫耐受中的作用是生殖健康中的一个重要课题。免疫耐受对于成功妊娠至关重要，涉及涉及各种免疫细胞和分子的复杂免疫反应。dNK 细胞构成了蜕膜中发现的最大的淋巴细胞亚群，在维持免疫耐受方面发挥着重要作用。这些细胞通过多种功能来维持蜕膜微环境的平衡，包括调节滋养细胞浸润、促进胎儿发育、调节子宫内膜蜕膜化和螺旋动脉重塑。dNK 细胞还可以根据其 NK、NK 和 NK 细胞的功能进一步分为不同的亚群。然而，dNK 细胞功能与妊娠结局之间的关系复杂且知之甚少。在这篇综述中，我们将重点介绍 dNK 细胞在妊娠期间的生理作用，并强调其在病理性妊娠和治疗方法中的潜在作用。
