Liu Tianlong, Wang Wenjun, Li Xiaolin, Chen Yidan, Mu Fei, Wen Aidong, Liu Minna, Ding Yi
Department of Pharmacy, The 940th Hospital Joint Logistics Support Forces of PLA, Lanzhou, China.
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Phytother Res. 2023 Dec;37(12):5509-5528. doi: 10.1002/ptr.7994. Epub 2023 Aug 28.
The pathogenesis of ischemic stroke is complex, and PI3K/Akt signaling is considered to play a crucial role in it. The PI3K/Akt pathway regulates inflammation, oxidative stress, apoptosis, autophagy, and vascular endothelial homeostasis after cerebral ischemia; therefore, drug research targeting the PI3K/Akt pathway has become the focus of scientists. In this review, we analyzed the research reports of antiischemic stroke drugs targeting the PI3K/Akt pathway in the past two decades. Because of the rich sources of natural products, increasing studies have explored the value of natural compounds, including Flavonoids, Quinones, Alkaloids, Phenylpropanoids, Phenols, Saponins, and Terpenoids, in alleviating neurological impairment and achieved satisfactory results. Herbal extracts and medicinal formulas have been applied in the treatment of ischemic stroke for thousands of years in East Asian countries. These precious clinical experiences provide a new avenue for research of antiischemic stroke drugs. Finally, we summarize and discuss the characteristics and shortcomings of the current research and put forward prospects for further in-depth exploration.
缺血性中风的发病机制复杂，PI3K/Akt信号通路被认为在其中起关键作用。PI3K/Akt通路在脑缺血后调节炎症、氧化应激、细胞凋亡、自噬和血管内皮稳态；因此，针对PI3K/Akt通路的药物研究已成为科学家们关注的焦点。在本综述中，我们分析了过去二十年中针对PI3K/Akt通路的抗缺血性中风药物的研究报告。由于天然产物来源丰富，越来越多的研究探索了包括黄酮类、醌类、生物碱类、苯丙素类、酚类、皂苷类和萜类在内的天然化合物在减轻神经功能缺损方面的价值，并取得了满意的结果。在东亚国家，草药提取物和中药方剂已应用于缺血性中风的治疗数千年。这些宝贵的临床经验为抗缺血性中风药物的研究提供了新途径。最后，我们总结并讨论了当前研究的特点和不足，并提出了进一步深入探索的前景。
