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唐棣素及其糖苷的研究进展。

Research Progress of Tamarixetin and its Glycosides.

机构信息

School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.

Ningxia Minority Medicine Modernization Key Laboratory of Ministry of Education, Yinchuan, 75004, China.

出版信息

Mini Rev Med Chem. 2024;24(7):689-703. doi: 10.2174/1389557523666230828123425.

Abstract

Tamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, antiinflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that tamarixetin is safe to use because it has little self-toxicity. In this paper, 181 articles on tamarixetin published from 1976 to 2023 are obtained from PubMed, China Knowledge Base Database, Wanfang Data, and other electronic databases. Tamarixetin is searched based on keywords, and 121 articles remain. Transformation synthesis, pharmacokinetics, pharmacological action, and structureactivity relationship of tamarixetin were reviewed.

摘要

柽柳素及其糖苷广泛分布于天然植物中,也是槲皮素的天然类黄酮衍生物。其主要药理作用包括抗氧化、抗炎、抗病毒、抗癌、心血管作用等。药代动力学显示,直接吸收的分布与生物合成不同。同时,研究表明柽柳素使用安全,因为它的自毒性很小。本文从 PubMed、中国知识资源总库、万方数据等电子数据库中获取了 1976 年至 2023 年发表的 181 篇关于柽柳素的文章,基于关键词对柽柳素进行检索,保留了 121 篇文章。综述了柽柳素的转化合成、药代动力学、药理作用和构效关系。

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